None listed
Conditions
Brief summary
The ingestion of fructose monosaccharide raises the concentration of uric acid in the blood as a result of metabolic processes occurring in the liver. The primary purpose of the study is to ascertain whether the rate of fructose absorption influences the amount of uric acid that subsequently enters the bloodstream as a result of liver metabolism. To generate a difference in the rate of fructose absorption we will be using two different disaccharides (disaccharides are sugars that comprise two monosaccharides that are joined by a bond). Table sugar (sucrose) is a disaccharide comprising half glucose and half fructose. Isomaltulose is a less commonly used sugar, but it also is a disaccharide comprising glucose and fructose. The difference between sucrose and isomaltulose is in the bond; the sucrose bond is more rapidly broken than the isomaltulose bond. The research question is whether the rate of fructose uptake by the liver influences the production of uric acid. Our hypothesis is that the concentration of uric acid in the blood will be greater following sucrose ingestion than it will after isomaltulose ingestion. A secondary outcome is the glycaemic response. We hypothesise that the faster breakdown of sucrose will result in a more rapid increase in blood glucose compared with the isomaltulose treatment.
Interventions
This will be a crossover trial in which 12 healthy adults will ingest a 500ml beverage containing either 50g of sucrose or a beverage containing a mix of 50g isomaltulose with 45mg sucralose. The order in which participants receive the beverages will be randomised to each person. There will be a minimum 2 day washout between beverages. Prior to the intervention, participants will be given a standard lunch of sushi and water. Participants will consume the intervention beverages 1.5hr following lu
This will be a crossover trial in which 12 healthy adults will ingest a 500ml beverage containing either 50g of sucrose or a beverage containing a mix of 50g isomaltulose with 45mg sucralose. The order in which participants receive the beverages will be randomised to each person. There will be a minimum 2 day washout between beverages. Prior to the intervention, participants will be given a standard lunch of sushi and water. Participants will consume the intervention beverages 1.5hr following lunch. Eating lunch and subsequent blood sampling will be under the supervision of the study investigators.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy adults with normal fasting blood glucose concentration
Exclusion criteria
Having a fasting blood glucose concentration >6.1mmol/L indicative of impaired fasting glucose
Outcome results
None listed