Tonsil and adenoid analysis study to investigate the causes of large tonsils and adenoids in children undergoing surgical removal of the tonsils and adenoids.

Conditions

None listed

Brief summary

Patients with a diagnosis of adenoid or tonsillar hyperplasia requiring surgery will be recruited from the Paediatric ORL Clinic at Auckland Hospital. We will then follow these patients through to surgery and gain consent for the use of a small amount of the tissue that is removed from the adenoids and the tonsils at the time of surgery and then take this tissue to the laboratory for analysis. We will look at the bacteria on the surface of the tissue and the bacteria within the tissue to determine if there is any difference between the two. We will then aim to use these results to determine what is causing these disease processes so that our understanding of how to treat them will increase. In addition, normal control samples (nasopharyngeal and tonsillar swabs from paediatric patients having general anaesthetics for conditions not affecting the upper airways) will be obtained in order to compare our results from patients with disease to patients without disease.

Related papers

No related papers found yet.

Interventions

Patients with a diagnosis of adenoid or tonsillar hyperplasia requiring surgery will be recruited from the Paediatric ORL Clinic at Auckland Hospital. We will then follow these patients through to surgery and gain consent for the use of a small amount of the tissue that is removed from the adenoids and the tonsils at the time of surgery and then take this tissue to the laboratory for analysis. We will look at the bacteria on the surface of the tissue and the bacteria within the tissue to determi

Patients with a diagnosis of adenoid or tonsillar hyperplasia requiring surgery will be recruited from the Paediatric ORL Clinic at Auckland Hospital. We will then follow these patients through to surgery and gain consent for the use of a small amount of the tissue that is removed from the adenoids and the tonsils at the time of surgery and then take this tissue to the laboratory for analysis. We will look at the bacteria on the surface of the tissue and the bacteria within the tissue to determine if there is any difference between the two. We will then aim to use these results to determine what is causing these disease processes so that our understanding of how to treat them will increase. In addition, normal control samples (nasopharyngeal and tonsillar swabs from paediatric patients having general anaesthetics for conditions not affecting the upper airways) will be obtained in order to compare our results from patients with disease to patients without disease.

Eligibility

Sex/Gender

All

Age

3 Years to 16 Years

Healthy volunteers

No

Inclusion criteria

Age between 3 and 16 years. Undergoing otolaryngology surgery for non-infectious pathology. Patients selected following study participant recruitment to represent age, ethnicity, and gender of participant population group.

Exclusion criteria

Patients with genetic syndromes, metabolic disorders, neurologic diseases or congenital malformations will be excluded. Patients with anatomical abnormality of the upper aerodigestive tract. Patients who have had antibiotics within the 2 weeks prior to surgery. Previous adenoidectomy, tonsillectomy, or grommet insertion.

Outcome results