Pulmonary artery pulsatility during and after exacerbations of chronic obstructive pulmonary disease (COPD): a prospective observational cohort study

Pulmonary artery pulsatility during and after exacerbations of COPD: a prospective observational cohort study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12617001562369

Acronym

PAPA COPD

Enrollment

152

Registered

2017-11-17

Start date

2018-02-12

Completion date

2021-02-28

Last updated

2018-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Many patients with Chronic Obstructive Pulmonary Disease (COPD) also have elevated lung blood pressures, or pulmonary hypertension (PH). Having both conditions increases the risk of death. It is difficult to diagnose PH in COPD. We will be using a new Computed Tomography (X-ray imaging) technique to investigate a marker of PH called ‘pulmonary artery pulsatility’. If PH can be diagnosed easily and accurately new treatments can be devised and researched potentially improving outcomes in COPD.

Interventions

Single centre prospective observational longitudinal cohort study with 12 months follow up. Hospitalised patients with acute exacerbations of COPD will be recruited, and undergo CT at baseline and after 12 months. This CT will measure a parameter called pulmonary artery pulsatility (a dynamic CT measurement of pulmonary artery diameter).

Eligibility

Sex/Gender

All

Age

35 Years to 85 Years

Healthy volunteers

Inclusion criteria

Acute exacerbations of COPD admitted to Monash Medical Centre, Clayton, Victoria, Australia Sinus rhythm

Exclusion criteria

WHO group I or III pulmonary hypertension Unable to undergo CT (eg allergy to intravenous iodinated contrast, egfr <60, weight >204kg due to scanner limitations, pregnant) Unable to consent or participate in follow up

Outcome results