Probiotics, immune health and sleep disruption

Moderating the effect of sleep disruption / deprivation on gut health and the immune system with probiotics in night shift workers

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617001552370

Enrollment

Registered

2017-11-13

Start date

2018-01-30

Completion date

2019-04-12

Last updated

2019-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Sleep deprivation / disruption is common across various population cohorts and is linked to poor health, decreased productivity and higher stress. Animal and human studies report a variety of changes to the immune system in response to sleep disruption/deprivation which may underpin the associated adverse health outcomes. Probiotic supplements have a strong evidence base for reducing gastrointestinal and respiratory illness and may be useful in a range of other diseases. These beneficial effects of probiotics are proposed to be via modulation of immune parameters. This study aims to investigate the effects of probiotic supplementation on alterations in indicies of immune and gut health associated with sleep disruption in an adult population. A double-blind placebo-controlled parallel group three-arm study will be undertaken in 90 adults who experience disrupted sleep due to shift work. A range of biological markers (reflecting immune and gut health) will be assessed before and after supplementation in association with sleep disruption.

Interventions

Treatment 1 (group 1) - Lactobacillus acidophilus 10billion cfu/day. Administered orally (capsule form) once per day for 28 days. Treatment 2 (group 2) - Bifidobacterium lactis 10billion cfu/day. Administered orally (capsule form) once per day for 28 days. Individuals will be randomly allocated to one treatment group only. Compliance will be assessed by return of unused supplement at the completion of the intervention.

Study design

Allocation

Randomised controlled trial

Primary purpose

Prevention

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

engaged in a rotating work roster involving night shift work

Exclusion criteria

• Has consumed probiotics, antibiotics or prebiotics in the previous 8 weeks • Has undergone treatment with systemic corticosteroids in the previous 6 months • uses immune-modulating medications or medications that alter sleep onset/quality • Is pregnant or possibly pregnant • Has current illness with a bacterial or viral infection

Outcome results