Effect of almond supplementation on pregnancy-induced hypertension and dyslipidemia

Effectiveness of almonds in pregnancy-induced hypertension and dyslipidemia

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617001548325

Acronym

APHD

Enrollment

Registered

2017-11-10

Start date

2016-01-25

Completion date

2016-06-15

Last updated

2017-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Pregnancy-associated hypertension and dyslipidemia are among the major causes of maternal deaths. There are myriad of safety concerns with the use of drugs in pregnancy. Several clinical trials have indicated the beneficial effects of almond on the cardiovascular system including our recent clinical trials showing HDL increasing potential of almonds. While exploring the underlying mechanism we found amelioration of vascular dysfunction by almonds, indicating therapeutic potential in hypertension. Keeping in view the lack of almond-intervention trials on hypertensive patients we aim to conduct a randomized controlled clinical study on hypertensive and dyslipidemic pregnant women visiting the consultant clinics at the Aga Khan Maternity Hospital, Karimabad, Karachi. The objective is to access the effectiveness of almonds in pregnancy-associated hypertension and/or dyslipidemia.

Interventions

Dietary intervention: whole raw almond Dose: 10 almonds/day Duration: 12 weeks Mode: Eaten before breakfast Adherance monitored through food diaries and regular phone calls (1-2 times per week)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Pregnancy-induced hypertension and/or dyslipidemia

Exclusion criteria

any serious comorbidities

Outcome results