None listed
Conditions
Brief summary
The aim of this study is to evaluate the feasibility of MRI only planning for rectal, anal canal and gynaecological cancer radiation therapy. Who is it for? You may be eligible to join this study if you are aged 18 years or over and have a histological diagnosis of a malignancy of the rectum, anal canal, cervix or endometrium and are about to be treated definitively with radical Radiotherapy at Calvary Mater Newcastle. Study details All participants enrolled into this study will receive an additional MRI scan at the Diagnostic Imaging Department, Calvary Mater Newcastle, scheduled on the same day as the participants planning CT scan. There will be no change to the participant’s treatment in this study – they will receive the gold standard of care and treatment as per departmental protocols. The MRI scan will be used for comparative purposes only. The MRI will be used to create a "synthetic CT scan" which will be used prospectively to compare to the participants previously acquired CT scan. The use of MRI alone for radiotherapy planning will eliminate the potential inaccuracies in the current fusion process between the MRI and CT scan. This method has the potential to improve radiotherapy planning techniques by better utilising the superior soft tissue contrast that MRI affords.
Interventions
The study involves an additional MRI scan being required for the study. This will require attendance at one MRI scan session of a half hour duration from the participant. This modification does not affect the gold standard of imaging the patients would otherwise receive for their treatment. This MRI scan will be undertaken at the Diagnostic Imaging Department, Calvary Mater Newcastle, scheduled on the same day as the participants planning CT scan. There will be no change to the participant’s tre
The study involves an additional MRI scan being required for the study. This will require attendance at one MRI scan session of a half hour duration from the participant. This modification does not affect the gold standard of imaging the patients would otherwise receive for their treatment. This MRI scan will be undertaken at the Diagnostic Imaging Department, Calvary Mater Newcastle, scheduled on the same day as the participants planning CT scan. There will be no change to the participant’s treatment in this study – they will receive the gold standard of care and treatment as per departmental protocols. The MRI scan will be used for comparative purposes only. The MRI will be used to create a "synthetic CT scan" which will be used prospectively to compare to the participants previously acquired CT scan
Sponsors
Laura O'Connor
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. >18 years of age 2. Patient able to provide informed consent 3. Histological diagnosis of a malignancy of the rectum, anal canal, cervix or endometrium 4. To be treated definitively with radical Radiotherapy +/- concurrent chemotherapy +/- surgery 5. Suitable for IMRT or VMAT planning
Exclusion criteria
1. ECOG performance status >1 2. Clinical evidence of distant metastatic disease 3. Women who are pregnant or lactating 4. Inability to have a MRI due to: a. Implanted magnetic metal e.g. intraocular metal, aneurysm clip, or other metallic implant b. Pacemaker/ implanted defibrillator c. Extreme claustrophobia 5. Mental impairment/intellectual impairment in which the patient would have difficulty giving informed consent to the study 6. Bariatric patients (patients with a BMI > 30)
Outcome results
None listed