None listed
Conditions
Brief summary
The research study will investigate the effect a common blood pressure tablet has on patients undergoing elective surgery. Participants will be randomly assigned to continue or cease their angiotensin converting enzyme inhibitors and angiotensin receptor blockers at least one day before their operation. Researchers will collate and analyze routinely collected patient information to detect if continuation or cessation results in better outcomes for the participants.
Interventions
Withholding angiotensin converting enzyme II inhibitors (ACEi) and angiotensin receptor blockers (ARBs) medication at least twenty-four hours prior to noncardiac surgery. The commencement of ACEi and ARB after surgery will be independent of the clinical trial and at the discretion of the treating clinician.
Sponsors
Metro South Health - Princess Alexandra Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Adult (>18 years of age) • Non-pregnant • Patients at Princess Alexandra Hospital (Brisbane, Queensland) • Attendance at preadmission clinic at least twenty-four hours prior to day of surgery • Elective surgery • Planned general anaesthetic • Prescribed an ACEi or ARB on a stable dose for the previous twenty-eight days
Exclusion criteria
• Systolic blood pressure greater than 180 mmHg noted on preadmission clinic visit • Cardiac surgery • Transplant surgery • Cognitive impairment or other neurological disorders resulting in patients lacking capacity to provide informed consent and a legally authorized substitute decision maker (power of attorney or statutory health attorney or appointed guardian) does not exist or is unavailable to provide informed consent.
Outcome results
None listed