None listed
Conditions
Brief summary
Many patients who require surgery on the shoulder experience significant post operative pain, particularly after their nerve block wears off. Despite the use of conventional analgesia many patients remain uncomfortable during this period. The aim of this project is to determine whether giving magnesium prior to surgery can improve this pain experience. The study proposes to give a single dose of magnesium to patients immediately prior to surgery and to assess their level of pain after surgery. This will involve the use of a subjective pain rating scale (1-10), and documentation of analgesic requirement. Patients will be randomly selected to receive either magnesium or placebo saline solution in order to assess the benefits of magnesium. Magnesium itself is a safe drug commonly used in clinical medicine for a number of different conditions.
Interventions
Patients will be administered 50mg/kg of intravenous Magnesium Sulphate at a rate of less than 8g/hr immediately prior to surgery while monitored in the holding bay. This will take place over 30-60 minutes at the anaesthetists discretion. Magnesium sulphate infusion is an established therapy often used in intensive care and the obstetric patient suffering pre-eclampsia. Experience has shown it has a very safe side effect profile. Normal dosage given for previously mentioned indications is 40-50m
Patients will be administered 50mg/kg of intravenous Magnesium Sulphate at a rate of less than 8g/hr immediately prior to surgery while monitored in the holding bay. This will take place over 30-60 minutes at the anaesthetists discretion. Magnesium sulphate infusion is an established therapy often used in intensive care and the obstetric patient suffering pre-eclampsia. Experience has shown it has a very safe side effect profile. Normal dosage given for previously mentioned indications is 40-50mg/kg. The recommended rate of administration is no greater than 8g per hour. Our regimen is in accordance with these guidelines.
Sponsors
Melbourne Orthopaedic Group
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
These are patients scheduled for elective open shoulder surgery.
Exclusion criteria
Patients with a chronic pain syndrome, conduction defect or pacemaker, or inability to communicate VAS scoring due to language or miscomprehension will be excluded from this study.
Outcome results
None listed