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Cancer And Physical ACtivITY (CAPACITY) trial: A randomised control trial of exercise and self-management for people with lung cancer

Cancer And Physical ACtivITY (CAPACITY) trial: A randomised control trial to evaluate the effect of exercise and self-management on physical function in people with lung cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617001283369
Acronym
Cancer And Physical ACtivITY (CAPACITY) trial
Enrollment
116
Registered
2017-09-06
Start date
2017-11-23
Completion date
2022-07-11
Last updated
2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will evaluate the effect of an exercise and education self-management program on physical function and functional recovery in people undergoing surgery for lung cancer. Who is it for? You may be eligible to join this study if you are aged 18 years or above, plan to undergo surgical treatment for non-small cell lung cancer (NSCLC), and do not currently meet physical activity guidelines. Study details Participants in this study will be randomly allocated (by chance) to one of two groups. Participants in one group will continue to receive usual care throughout the study. Participants in the other group will receive an exercise and education self-management program in addition to usual care. The program consists of an appointment with a physiotherapist before hospital discharge post-operatively. Additionally, the patient will receive weekly phone calls up to 12 weeks after surgery to promote adherence to physical activity goals, discuss barriers/issues with their exercise and progress their exercise program. All participants will undergo a number of tests including measurement of physical function, quality of life and physical activity before surgery, at hospital discharge, and 3 and 6 months post-surgery. We will also follow up to look at quality of life, health care resource usage and the cost effectiveness of the intervention over 12 months from surgery, and survival up to 5 years post-surgery. This study will provide important information on the effects of an exercise based intervention for people with lung cancer.

Interventions

Intervention arm: In addition to usual care, participants randomised to the intervention arm will also receive an exercise and education self-management program after surgery. The intervention implements the American College of Sports Medicine Physical Activity Guidelines for people with cancer (Schmitz et al Med Sci Sports Exer 2005;14). The program consists of a face to face appointment with a physiotherapist occur post-operatively on the hospital ward before discharge. The session can be spli

Intervention arm: In addition to usual care, participants randomised to the intervention arm will also receive an exercise and education self-management program after surgery. The intervention implements the American College of Sports Medicine Physical Activity Guidelines for people with cancer (Schmitz et al Med Sci Sports Exer 2005;14). The program consists of a face to face appointment with a physiotherapist occur post-operatively on the hospital ward before discharge. The session can be split over two times/days if needed, with a total duration of 15 to 45 minutes (depending on the needs of the participant). The session(s) include 1) assessing the patient’s readiness for physical activity behavioural change, goals and confidence; 2) verbal education with the patient +/- carers and family about physical activity; 3) provision of resources to support physical activity (including an activity monitor, exercise diary and booklet); 4) setting personalized physical activity goals with the patient and a home program; and 5) identifying barriers and enablers for the patient to achieve the physical activity goals. All participants will be prescribed a home walking program and this will be progressed towards performing 150 minutes per week at a moderate intensity based on the American College of Sports Medicine Physical Activity Guidelines for people with cancer (Schmitz et al Med Sci Sports Exer 2005;14). In addition participants will be prescribed a home resistance training program, using body weight, that are targeting major muscle groups and progressed towards performing this two to three times per week. The exercises including type of exercise, repetition number, frequency and duration are tailored to the individual patient's ability. The intervention is personalised to the individual participant’s needs because patients with lung cancer present with other comorbid disease, including depression and COPD, and therefore to improve efficacy a targeted approach to physical activity is required that addresses the participants individual goals and that can be prescribed from their current physical activity levels. The patient will receive weekly phone calls to promote adherence to the set physical activity goals, discuss barriers/issues and progress exercise. The phone calls occur weekly after hospital discharge for 3 months. The duration of the phone calls will be 5 to 20 minutes each depending on the needs of the participant. Participants will be asked to keep an exercise diary during the intervention period to record their daily exercises and physical activity levels.

Sponsors

The University of Melbourne
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

- Adults, aged 18 years or over - Able to provide consent - Planned to receive surgical treatment for non-small cell lung cancer (NSCLC) - Expected to be alive > 6 months - Eastern Cooperate Oncology Group (ECOG) performance status of 0-2 at study entry - Not currently meeting the physical activity guidelines (150 minutes of moderate intensity physical activity or 75 minutes of vigorous physical activity per week)

Exclusion criteria

- Non-English speaking (insufficient English language skills to complete the questionnaires) - Metastatic disease (stage IV lung cancer) - Acute uncontrolled cardiovascular or respiratory issues - Decompensated heart failure, severe aortic stenosis, uncontrolled arrhythmia, or acute coronary syndrome - Non-ambulant (for example: amputee, spinal cord injury, wheel-chair bound) - ECOG performance status of 3 or 4 at study entry - Cognitive impairment (determined as not being able to provide consent for surgery)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 13, 2026