None listed
Conditions
Brief summary
Purpose of the research Significant weight gain and poorly controlled blood pressure are commonly seen in patients with end stage renal disease on intermittent hemodialysis. There is evidence that these complications are due to not enough salt being removed from the body during hemodialysis. The hemodialysis machine currently uses a standard strength of sodium during each hemodialysis session. If this concentration is reduced, this may improve blood pressure control and decrease the amount of weight gained between dialysis sessions. The reason we are doing this research is to find out if the low sodium fluid is better than the regular concentration that is currently being used.
Interventions
Intervention phase: alteration of sodium bath concentration in dialyser from 140mEq/L to 136mEq/L
-Participants will be provided an information sheet explaining the intervention and purpose of the study
-Dialysis nurses (competent to deliver a dialysis service) will alter settings on the machine to allow change in sodium bath. Participants will otherwise undergo their normal dialysis treatment in the unit.
-Delivery of the intervention will take place at each dialysis session.
- The interven
Intervention phase: alteration of sodium bath concentration in dialyser from 140mEq/L to 136mEq/L -Participants will be provided an information sheet explaining the intervention and purpose of the study -Dialysis nurses (competent to deliver a dialysis service) will alter settings on the machine to allow change in sodium bath. Participants will otherwise undergo their normal dialysis treatment in the unit. -Delivery of the intervention will take place at each dialysis session. - The intervention will be performed at each dialysis session (three sessions per week) for a total of 8 weeks - Initially the bath concentration will be decreased from 140mEq/l to 138mEq/l for 1 week (three treatment sessions) and then to 136mEq/l for the remainder of the data collection period - The intervention will occur within the haemodialysis unit (Townsville Hospital; North Ward Satellite Clinic) The intervention will be applied to all eligible participants Participants will need to attend their usual planned haemodialysis treatment to receive the intervention. Adherence: -Dialysis nurses routinely call patients when they do not attend their planned haemodialysis treatment; social workers provide assistance for community-based transport for those who require it; 2. The 8 week control period will be performed prior to the 8 week intervention period for every participant.
Sponsors
The Townsville Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Patients aged between 18 and 90 years 2. Patients on maintenance haemodialysis for at least 6 months 3. Patients with significant IDWG (2 kilogram or more) with or without associated uncontrolled hypertension 4. Patients who are medically stable with no other acute issues that can affect the study outcome
Exclusion criteria
1. Patients who have cardiac failure and cardiovascular compromise 2. Patients who are admitted to hospital for acute illness 3. Patients who are hyponatraemic (sodium <135) 3. Patients prone for hypotension 4. Patients who are pregnant 5. Patients who are homeless
Outcome results
None listed