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Neural Repair and Sleep in Traumatic Brain Injury ('TBI'): an observational study to investigate the recovery of sleep after TBI.

Neural Repair and Sleep in Traumatic Brain Injury ('TBI'): an observational study to investigate the recovery of sleep after TBI.

Status
Suspended
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12617001232325
Acronym
NRSleepTBI
Enrollment
30
Registered
2017-08-23
Start date
2017-10-02
Completion date
2019-09-02
Last updated
2021-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this study is to investigate the brain signalling in sleep after TBI. We want to know if sleep problems improve as time passes after the brain injury, and whether the recovery of sleep, sleep quality, and cognition are related. It is also possible that some patients after a severe TBI have breathing problems in sleep. It is possible that breathing problems in sleep could affect their recovery. The sleep study will include monitoring for breathing disorders during sleep.

Interventions

This is an observational study of sleep in traumatic brain injury (TBI) in the inpatient rehabilitation setting. The study will seek to study sleep fragmentation and its recovery over time in TBI. The study will also examine the effect of sleep fragmentation and self-reported sleep quality on cognition, behaviour, mood, disability and life satisfaction. Polysomonography (PSG) with electroencephalography (EEG) assessments with clinical assessments will be repeated fortnightly for up to 6 weeks

This is an observational study of sleep in traumatic brain injury (TBI) in the inpatient rehabilitation setting. The study will seek to study sleep fragmentation and its recovery over time in TBI. The study will also examine the effect of sleep fragmentation and self-reported sleep quality on cognition, behaviour, mood, disability and life satisfaction. Polysomonography (PSG) with electroencephalography (EEG) assessments with clinical assessments will be repeated fortnightly for up to 6 weeks following post-traumatic amnesia (PTA) resolution. If PSG with EEG is not feasible, an overnight pulse oximetry will be offered.

Sponsors

Royal Rehab Brain Injury Unit
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Age 16 years and over at injury; treated in a non-paediatric healthcare system; a blunt head trauma with a clear description of injury for head trauma; current inpatient in a public hospital; neuroimaging with CT and, or, MRI brain performed at 4 weeks or less following injury and images or reports are available for viewing.

Exclusion criteria

Restless or disruptive behaviour; psychiatric instability.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026