Effect of orally given pregabalin before knee joint replacement on incidence of bandage induced reperfusion injury

None listed

Extremity surgeries require tourniquet for a bloodless surgical area. But, tourniquet applications cause ischemia-reperfusion injury. Our aim in this study is to investigate effect of preoperatively given pregabalin, GABA analog drug, on the tourniquet induced ischemia-reperfusion injury. 54 patients between 18-65 years who undergo total knee arthroplasty participate the study. Criteria for inclusion are patients whom American Society of Anesthesiologists (ASA) physical status I-II, undergoing a total knee arthroplasty surgery, accept neuroaxial anesthesia for surgery. Criteria for exclusion are patients who use any antiepileptic drug, allergic reaction to pregabalin, severe hepatic, renal or gastrointestinal disorders, physciatric disorders, pregnants or breastfeeding, NSAID or opioid drug use for a long time, diabetic or other neuropathic pain. We randomize patients into two groups. 1) Pregabalin group 2) Control group We give pregabalin 150 mg orally to pregabalin group patients two times (first dose 1 day before surgery., second dose 1 hour before surgery). We give placebo drug at the same times to the control group. We perform combined spinal epidural anesthesia for surgery. we give 3 cc 0.5% hyperbaric bupivacaine for spinal anesthesia. We take blood samples for measurement of ischemia-reperfusion determinants, immediately before surgery, 5 minutes before tourniquet deflation, and 20 minutes after tourniquet deflation. We compare these results with appropriate statistical methods.

No related papers found yet.