None listed
Conditions
Brief summary
RCT of vitamin C versus glucosamine to improve ulcer healing in people attending the high-risk foot clinic. The hypothesis is that vitamin C will improve ulcer healing. We also predict that it will be more effective in people with diabetes, and people who are deficient in vitamin C at the beginning of the study.
Interventions
Randomised, controlled trial of supplementation with vitamin C versus glucosamine (the 'placebo') for healing of foot ulcers.
Daily, oral capsule, 500mg of vitamin C, up to 60 days. Empty packet return will be used to assess compliance. In people in whom baseline levels are low, from the return of the result, they will receive BOTH supplements (so the first part of the study remains blinded).
Sponsors
Research and Education Network, Westmead Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
New presentation to high-risk foot clinic at Westmead hospital. Only people with a foot ulcer can attend this clinic.
Exclusion criteria
Not a new patient for the clinic. Bilateral below knee amputations. Inability to give informed consent. Unable to take vitamin C / glucosamine tablets
Outcome results
None listed