None listed
Conditions
Brief summary
The primary purpose of this research is to determine whether consuming a polyphenol-rich seaweed supplement for 12 weeks will reduce LDL cholesterol levels in adults with elevated LDL cholesterol at baseline. It is hypothesised that the group who receive the seaweed extract supplement will have a greater reduction in LDL cholesterol levels than the group who receive the rice flour supplement.
Interventions
The intervention consists of 12 weeks supplementation with a commercially available polyphenol-rich seaweed extract, called Maritech Synergy.
The extract will be consumed in the form of oral tablets, in a dose of 2000 mg extract (containing 600 mg polyphenols) taken daily, over the course of 12 weeks.
Adherence will be assessed by collecting used tablet boxes from participants and counting the leftover tablets, as well as through the use of a check off chart.
Sponsors
Monash University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Body mass index from 27 to 35 kg/m2 (25 to 35 kg/m2 for people of Asian background) Fasting LDL cholesterol level above 2.0 mmol/L
Exclusion criteria
Gastrointestinal issues that may affect the absorption and intestinal actions of the polyphenols, Taking medication for cholesterol or blood pressure control or any other medications that may influence results. Taking other natural health products known to impact on polyphenols e.g. fish oil, Women who are breastfeeding or pregnant, Individuals with liver/thyroid issues, Having undergone major surgery in the past 6 months, Consuming more than 4 standard drinks per day, or 14 standard drinks per week, Cigarette smoking. Having an implanted cardiac defibrillator. Individuals with depression, anxiety or dementia (cognitive aspect only)
Outcome results
None listed