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KiwiC for Vitality Study: Effect of kiwifruit on Vitality, Fatigue and Wellbeing

Kiwifruit and Vitality: a randomised controlled trial on the effect of kiwifruit on vitality, fatigue and wellbeing in participants with low vitamin C status

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617001031358
Enrollment
155
Registered
2017-07-17
Start date
2017-09-04
Completion date
2018-04-19
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to assess the effect of adding SunGold kiwifruit to the diet on changes in vitality, fatigue, and wellbeing. The study aims to determine whether any improvements in these outcomes can be attributed to the high vitamin C content of the fruit. In a previous pilot study, we observed that intake of two kiwifruit/day for six weeks provided a significant 31% increase in vigour and a significant 38% decrease in fatigue in young men with a higher than average total mood disturbance score as assessed by the Profile of Mood States (POMS) questionnaire. Interestingly, intake of half a kiwifruit/day did not have any effect on mood scores, suggesting a dose dependency. We are now proposing a larger study that includes both men and women, has more extensive measures of vitality, fatigue and wellbeing, and includes a vitamin C and a placebo comparison arm. This randomised controlled trial brings together the expertise of Professor Margreet Vissers, Dr Anitra Carr and Dr Tamlin Conner, New Zealand's leading research experts in vitamin C bioavailability and function (Vissers and Carr) and psychological wellbeing (Conner). We will recruit participants who have low vitamin C status. Individuals will be randomised to one of three interventions: (1) Two SunGold kiwifruit per day; (2) vitamin C tablet daily (equivalent to the vitamin C content of two kiwifruit); (3) placebo tablet daily. We will monitor vitality/fatigue/wellbeing, using intermittent nightly smartphone surveys and traditional fortnightly assessments. The study will last for 8 weeks (2 week lead-in; 4 week intervention; 2 week washout period). Our hypothesis is that consumption of two SunGold kiwifruit per day will improve vitality, decrease fatigue, and improve wellbeing.

Interventions

Arm 1, Two SunGold kiwifruit per day for 4 weeks during the intervention period. The intervention period is preceded by a 2 week lead-in and followed by a 2 week washout where no intervention is given. Arm 2, One oral tablet containing 250 mg vitamin C per day for 4 weeks during the intervention period. The intervention period is preceded by a 2 week lead-in and followed by a 2 week washout where no intervention is given.

Sponsors

University of Otago, Christchurch
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

Plasma vitamin C levels <45 µmol/L Non-smoker

Exclusion criteria

Taking prescription medication (within past three months) Allergy/intolerance to Kiwifruit Recent smoker (within previous year) Taking vitamin C supplements (within past three months) High fruit/juice & vegetable consumption (greater than or equal to 5 servings/day) Excessive alcohol consumption ( greater than 21 standard drinks/week) Diabetes mellitus Bleeding disorders Fainting due to fear of needles

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 7, 2026