None listed
Conditions
Brief summary
Adenomyosis refers to a disorder in which glands lining the womb cavity present within the uterine musculature (uterine adenomyomatosis). The ectopic glandular tissue appears to induce thickening of the surrounding musculaure, which results in a diffusely enlarged womb.The medical treatment of adenomyosis is based on the hormonal dependency of the disease and its strongly share similarities with endometriosis,Two novel techniques will improve medical treatment over the next few years and even produce a preventive strategy: the first are new blood vessels inhibitors and the second is the progesterone-releasing intrauterine device
Interventions
Levonorgestrel medicated intrauterine device contain 52 mg of levonorgestrel , will be inserted by consultant ,as simple outpatient procedure . progestin provide a release rate of approximately 20mcg/day. It still reactive for five years, patient adherence checked one month then three months after insertion and every one year visit.
Sponsors
nahed allam
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
Women with symptomatic adenomyosis (menstrual irregularities –pain-subfertility): 1- Age more 30 years and less than 50. 2- Patients not seeking for fertility. 3- Patients were seeking an alternative to hysterectomy
Exclusion criteria
1. Uterine fundal level more than 20cm above symphysis pubis 2. Active pelvic infection or current use of contraceptive 3. Contraindication for medications
Outcome results
None listed