None listed
Conditions
Brief summary
The purpose of this physiology study is to determine the effects of high dose zopiclone (15mg) on obstructive sleep apnoea severity, upper airway muscle activity, the respiratory arousal threshold and breathing parameters during sleep.
Interventions
High dose zopiclone (15mg), each participant to receive zopiclone once, immediately before bed. Zopiclone to be taken orally in front of the investigator for this acute in-laboratory study.
1 week washout between visits.
Sponsors
Neuroscience Research Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
Otherwise healthy, men and women with obstructive sleep apnoea Patients who have a low respiratory arousal threshold (between zero and -15cmH2O epiglottic pressure just prior to arousal) as estimated from their baseline sleep study.
Exclusion criteria
Patients with confirmed overnight blood oxygen saturation nadir (SaO2) less than 70% from baseline sleep study Patients with a high arousal threshold (less than -25cmH2O epiglottic pressure prior to arousal) Patients taking medications known to affect sleep or muscle activity Women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study Patients with any other medical condition which may interfere in the evaluation of the study
Outcome results
None listed