None listed
Conditions
Brief summary
Micronutrient deficiency can occur in adults if their diet is unbalanced or inadequate. The elderly are at a higher risk for nutritional deficiencies. Factors such as changes in digestion, metabolism and absorption of food due to ageing, limited food choices due to weakened teeth and restrictions to physical movement may account for this. Dietary supplements can aid in reaching adequate levels of micronutrient in adults. Among these, the largest category is combinations of vitamins and minerals that are formulated to deliver a large percentage (typically 50-100%) of the recommended daily intake (RDI). Yet, the clear difference in bioavailability of micronutrient from supplements between young and elderly adults have not been established. This study aims to investigate whether the bioavailability of a vitamin and mineral supplement is changed in the elderly, and to look at whether changes in bioavailability have an effect on metabolic processes. We hypothesise that the ageing will impair the bioavailability of vitamins and minerals, and that the metabolic profile will reflect these impairments..
Interventions
One tablet of multivitamin and mineral supplement to be consumed with a standard breakfast meal on one morning. Subjects will be fasted overnight prior to the intervention. The tablet will be consumed in full in the presence of the researchers to confirm compliance, to be ingested within 20 minutes. No additionally food or drink will be consumed during the 4 hour intervention. The multivitamin and mineral tablet to be consumed is Centrum Advance.
Centrum Advance Ingredients
Vitamin A (As Reti
One tablet of multivitamin and mineral supplement to be consumed with a standard breakfast meal on one morning. Subjects will be fasted overnight prior to the intervention. The tablet will be consumed in full in the presence of the researchers to confirm compliance, to be ingested within 20 minutes. No additionally food or drink will be consumed during the 4 hour intervention. The multivitamin and mineral tablet to be consumed is Centrum Advance. Centrum Advance Ingredients Vitamin A (As Retinyl Acetate) 300mcg (Retinal Equivalents) Lutein 500mcg Lycopene 600mcg Betacarotene 1.8mg Vitamin B1 2.18mg Vitamin B2 3.2mg Nicotinamide 15mg Vitamin B6 6mg Vitamin B12 22mcg Vitamin C 90mg Vitamin D3 15mcg Vitamin E 50mg Vitamin K1 25mg Biotin 45mcg Folic Acid 400mcg Calcium Pantothenate 10.8mg Calcium (As Calcium Carbonate 135.3mg, Calcium Hydrogen Phosphate 64.7mg) 200mg Phosphorus (As Calcium Hydrogen Phosphate) 50mg Potassium (As Sulfate) 80mg Chromium (As Chloride) 35mcg Copper (As Sulfate) 0.5mg Iodine (As Potassium Iodide) 150mcg Iron (As Ferrous Fumarate) 5mg Magnesium (As Oxide) 50mg Manganese (As Sulfate) 3.5mg Selenium (As Sodium Selenate) 55mcg Zinc (As Oxide) 7.5mg
Sponsors
University of Auckland
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
19 Years to 76 Years
Healthy volunteers
Yes
Inclusion criteria
Young adults – males and females aged 19-30 years Elderly adults – males and females aged 65-76 years Healthy BMI (18-30 kg/m2) Self-reported not consuming dietary supplements within 3 weeks No history of gastrointestinal disease or metabolic disease
Exclusion criteria
Are currently consuming multivitamin and mineral supplements Are diagnosed with gastrointestinal disease (i.e. celiac, Crohn’s, colitis, etc.) or pre-existing metabolic disease Are currently taking medications expected to interfere with normal digestive or metabolic processes including proton pump inhibitors, laxatives, etc. Have a medical history precluding a healthy state: history of myocardial infarction, angina, stroke, cancer or pre-existing diabetes, self-reported alcohol intake exceeding a moderate intake (>28 units per week)
Outcome results
None listed