The metabolic and body composition effects of a CREBRF gene variant in healthy adults

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617000956303

Enrollment

125

Registered

2017-07-04

Start date

2017-09-25

Completion date

Unknown

Last updated

2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Fat rather than body weight is the greatest risk factor for type 2 diabetes. Body mass index (BMI: calculated by height divided by weight squared) is often used as a measure of body fat. However, in some people it does not accurately reflect the amount of fat. This is interesting because it has recently been found that people with a small change (variant) in a gene called CREBRF have a higher BMI, but a LOWER risk of developing type 2 diabetes. In this study we are investigating whether people with a CREBRF gene variant have different lean (muscle) or fat mass, and we are trying to understand how this gene variant lowers the risk of developing type 2 diabetes

Interventions

Mixed meal tolerance test: A high carbohydrate (60g) and fat (20g) meal. Test food will be delivered in both a liquid drink and typical breakfast food. Blood samples (10ml) will be taken from a cannula pre meal and every 15-30 minutes for 2 hours, For the whole day the total volume of blood taken will be 250 ml, this is less than 1 cup and half the volume of a blood donation. This will occur at the clinic rooms at The University of Auckland and administered by the PI. We will also collect res

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

Aged 18-50 years, male or female.

Exclusion criteria

Have diabetes Have any long-term serious medical conditions

Outcome results