Comparison of effects of anesthetic selection in circumcision operations performed with different anesthetics

Comparison of effects of anesthetic selection on recovery in circumcision operations performed with ketamine-midazolam and ketamine-propofol anesthesia

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617000859381

Enrollment

Registered

2017-06-09

Start date

2017-02-01

Completion date

2017-03-01

Last updated

2017-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Objective:To compare the therapeutic effects of ketamine plus midazolam or ketamine plus propofol on analgesia, sedation, recovery time, side effects in premedicated children with midazolam who are prepared circumcision operation.Methods: 80 American Society of Anaesthesiologists physical status I---II children, aged between 5 and 12 years, undergoing circumcision operations under sedation were recruited according to a randomize and double-blind institutional review board-approved protocol. Patients were randomized into two groups via sealed envelope assignment. Both groups were administered of midazolam 0.04 mg/kg intravenously in the presence of parents in the pre-operative holding area. Patients were induced with midazolam-ketamine in Group I or ketamine-propofol in Group II. Results: In the between-group comparisons, age, weight, no difference was observed (p > 0.05). Recovery was faster in ketamine-midazolam group (p < 0.05). Conclusion: midazolam-ketamine provided faster recovery than ketamine-propofol in pediatric circumcision operations. We did not observe significant complications during sedation in these two groups. Therefore, ketomine-midazolam appears to provide a faster recovery for circumcision operation.

Interventions

first group: ketamin(2mg/kg)+midazolam(0,05mg/kg) were administered intravenously (single injection)-injections were done 3 mnutes before surgery start. second group: ketamin(1mg/kg) + propofol(3mg/kg) were adminsitered intravenously (single injection) for circumcision operation,injections were done 3 mnutes before surgery start. recovery from anesthesia according to hypnotic selection was assessed

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

Male

Age

5 Years to 12 Years

Healthy volunteers

Yes

Inclusion criteria

Parental consent 5-12 years children ASA I and II physical status Elective circumcision surgery

Exclusion criteria

if parental consent in not present ASA III or worst physical status Emergency procedures

Outcome results