The effect of insulin on blood flow to the heart during a heart attack.

The effect of hyperinsulinemic euglycemia on myocardial blood flow reserve in patients with obstructive coronary artery disease

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617000845336

Acronym

EHEMI

Enrollment

Registered

2017-06-08

Start date

2016-10-09

Completion date

2017-08-17

Last updated

2017-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The effect of hyperinsulinemic euglycaemia (HE) on myocardial ischaemia is unknown. We have previously shown that HE increases myocardial blood flow in healthy individuals. We speculate that following successful revascularisation of a myocardial infarction, HE can improve microvascular flow to both ischaemic and remote non-ischaemic myocardial territories.

Interventions

Intravenous administration of rapid-acting human insulin (rDNA) 1.5mU/kg/minute for 2 hours with concurrent administration of 25% glucose intravenously (dose titrated according to blood glucose aiming for a blood glucose within 10% baseline and greater than 4mmol/L).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

Aged 18-80 Acute ST elevation myocardial infarction planned for primary percutaneous coronary intervention for mechanical revascularisation OR emergent percutaneous coronary intervention for failed pharmacological thrombolysis. Able to provide written informed consent.

Exclusion criteria

Previous coronary or cardiac valvular intervention. On insulin therapy. Cardiogenic shock. Malignant life-threatening illness.

Outcome results