A study of the ability to achieve negative water balance in children undergoing continuous renal replacement therapy (CRRT) and its possible relation to mortality.

A retrospective cohort study of the ability to achieve negative water balance in critically ill children undergoing CRRT and its possible relation to mortality.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12617000753358

Enrollment

Registered

2017-05-22

Start date

2017-03-01

Completion date

2017-09-30

Last updated

2023-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Acute kidney injury is common in the PICU and is associated with fluid overload. Increasing degrees of fluid overload at the time of CRRT initiation is associated with increased mortality. It is unknown if the ability to achieve negative water balance is related to outcome, circuit life span and infectious control in children. The main purpose of this retrospective cohort study is to evaluate the association between possible inability to achieve negative water balance within 72 hours after CRRT initiation in critically ill children and mortality. We will retrospectively include all patients subjected to acute kidney injury and undergoing CRRT admitted to our PICU. The period of inclusion is set from 2009 until 2016.

Interventions

A retrospective observational trial where critically ill children subjected to acute kidney injury undergoing continuous renal replacement therapy (CRRT) are characterized. Patients are identified in the ICU database. The patients are primary studied to elucidate if ability to achieve or not to achieve negative water balance within the first 72 hours after CRRT is initiated is associated with increased mortality rate. The patients are observed during the entire PICU stay.

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

Critically ill children (age newborns up to 18 year) subjected to acute kidney injury and undergoing continuous renal replacement therapy (CRRT).

Exclusion criteria

All critically ill children not undergoing CRRT

Outcome results