None listed
Conditions
Brief summary
Alpha thalassemia is a common hematologic disorder in the gulf area with devastating long term sequelae. our hypothesis is to test the sensitivity of red blood cells indices mainly the mean corpuscular volume MCV as a screening test for an early diagnosis of the disease. All newborn infants delivered in Dubai hospital will be enrolled in the trial excluding infants with major congenital malformations. Full blood count will be carried on cord blood samples and cases with low MCV less than 90 fl are candidates for hemoglobin electrophoresis. Those with positive hemoglobin Bart will be examined for alpha thalassemia gene deletion detection by multiplex PCR method. These data will be recorded over 12 month period by neonatologists in NICU, Dubai hospital for statistical analysis at the end of the trial
Interventions
Alpha Thalassemia is a hereditary blood disorder occurring due to genetic defect causing deficient synthesis of hemoglobin polypeptide chains. it occurs with significant frequency in the gulf area and middle east.
The purpose of this prospective study is to evaluate the role of red blood cells indices mainly the mean corpuscular volume (MCV) as a screening tool for diagnosis of alpha thalassemia syndromes in UAE nationals born in Dubai hospital.
We will study the red blood cell indices namely t
Alpha Thalassemia is a hereditary blood disorder occurring due to genetic defect causing deficient synthesis of hemoglobin polypeptide chains. it occurs with significant frequency in the gulf area and middle east. The purpose of this prospective study is to evaluate the role of red blood cells indices mainly the mean corpuscular volume (MCV) as a screening tool for diagnosis of alpha thalassemia syndromes in UAE nationals born in Dubai hospital. We will study the red blood cell indices namely the MCV, mean corpuscular hemoglobin (MCH) ,hemoglobin level (Hb) , and Red cell distribution width (RDW) from umbilical cord blood samples of all eligible neonates delivered in Dubai Hospital in the period from june 2017 till june 2018. Hb electrophoresis will be carried on samples with low MCV less than 90 Fl. To evaluate the level of hemoglobin Barts . All cases with positive hemoglobin Barts will be assigned for alpha thalassemia gene deletion detection by multiplex PCR method. Umbilical cord blood samples will be collected by the registered obstetric nurse assigned in labour suit or operation theatre and data will be recorded by neonatology registrars using the designed study tool. Statistical analysis will be carried on by the end of the 12 month trial period.
Sponsors
dubai hospital
Study design
Allocation
Non-randomised trial
Primary purpose
Diagnosis
Eligibility
Sex/Gender
All
Age
1 Hours to 4 Weeks
Healthy volunteers
Yes
Inclusion criteria
All healthy neonates delivered at dubai hospital
Exclusion criteria
1- major congenital anomalies 2- inpatient neonates underwent exchange transfusion.
Outcome results
None listed