None listed
Conditions
Brief summary
The aim of the study is to explore the effect of cacao flavanols on cognition among older people (65-75 years) who have not been diagnosed any severe medical condition and has normal cognition. In addition, the changes in participants’ blood glucose and lipids will be analysed. The study is double blinded randomized controlled trial. Participants in the intervention group receive daily 50 grams dark chocolate that rich in flavanols, especially epicathecin. Control group receives 50 grams dark chocolate that is low in flavanols. Intervention lasts 8 weeks. Participants will be recruited in the metropolitan area of Finland. Inclusion criteria is 65-75 years of age and no severe health problems. According to power calculation total number of participants is 100. The main outcome measures are Verbal Flow (VF) and Trail Making Test (TMT). Food intake will be collected with food records for three days. Intakes of energy, nutrients and polyphenols will be assessed. Blood samples will be collected from the participants and changes in blood glucose and lipids will be measured.
Interventions
FlaSeCo-trial. Participants eat dark chocolate 50 g per day eight weeks time period. Chocolate in intervention group consists flavanols 400 mg per 50 grams and in control group less than 100 mg flavanols per 50 g. Participants keep diary by ticking with "x" after they had eaten their daily chocolate. Possible uneaten chocolate will be brought back at the end of intervention.
Sponsors
Society for Gerontological Nutrition in Finland
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
65 -75 years of age and informed consent
Exclusion criteria
BMI>32, smoking, use of statins. medication for hypertension
Outcome results
None listed