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Delayed effect of blackcurrant consumption on sugar metabolism in healthy adults

Delayed effect of blackcurrant consumption on the regulation of sugar metabolism and energy production in healthy adults.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617000733370
Acronym
None
Enrollment
30
Registered
2017-05-19
Start date
2017-05-01
Completion date
2017-07-24
Last updated
2017-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Scientific evidence suggests that berry fruit-derived polyphenolic compounds can regulate the digestion, absorption and utilisation of sugar. This presents an opportunity for the development of blackcurrant foods that regulate sugar metabolism and energy production. We have gathered proprietary information on the composition and bioavailability of NZ blackcurrant fruits and derived products, and now turn our focus to how to explore how the ‘timed’ consumption of blackcurrants influences sugar metabolism to maximise energy production. In particular pilot study, we aim to explore the delayed effect of blackcurrant consumption on sugar metabolism and energy production.

Interventions

This trial is aimed at assessing the delayed action of blackcurrant consumption on sugar metabolism and energy production. The trial is a parallel design consisting of two trial arms. This design was selected since the influence of blackcurrant on sugar metabolism is currently unknown; a parallel trial design will eliminate any potential problems from a cross-over design. In both trial arms, participants will be asked to fast for 12 hrs the night before and eat a set breakfast (One Square Meal

This trial is aimed at assessing the delayed action of blackcurrant consumption on sugar metabolism and energy production. The trial is a parallel design consisting of two trial arms. This design was selected since the influence of blackcurrant on sugar metabolism is currently unknown; a parallel trial design will eliminate any potential problems from a cross-over design. In both trial arms, participants will be asked to fast for 12 hrs the night before and eat a set breakfast (One Square Meal Bar [Cookie Time Ltd.]) 2 hrs before the start of the trial. Participants will be randomised into 2 trial arms; arm 1 will consume a 200 mL drink containing fruit sugar (equivalent to the amount in the blackcurrant extract, i.e. for 2.2 g glucose, 2.6 g fructose, 0.36 g sucrose) diluted in water and then 3 hr later a 200 ml sugar drink containing 40 g sucrose diluted in water, and arm 2 will consume a 200 ml a blackcurrant drink (containing a whole blackcurrant extract equivalent to 3.2 mg polyphenolic compounds /Kg) diluted in water and then 3 hrs later a 200 ml sugar drink containing 40 g sucrose diluted in water. The blackcurrant extract was commercially sourced from Sujon Berries (New Zealand) and the sugars purchased from Healtheries (New Zealand) and dinks were prepared under New Zealand food safety requirements. The trial will take place in designated clinical facilitates within PFR and will be conducted by experience trial co-ordinators, who are also First Aider and trained phlebotomist. The trial co-ordinator will monitor the welfare of participants and ensure that they adhere to trial arm protocols. Participants will be randomised into one of the two arms. In both arms a small amount of blood (capillary samples) will be taken prior to the start of the trial, 3hrs after the consumption fruit sugar or blackcurrant drinks and at specific times over a 2 hr period; 15, 30, 45, 60, 90 & 120 mins after the sucrose drink..

Sponsors

Jocelyn Eason
Lead SponsorOther

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy individuals (male or female) aged 16-60 years old. Individuals will be required to complete a health questionnaire and provide informed written consent.

Exclusion criteria

Individuals will be excluded if they are unwilling or unable to provide informed written consent or comply with the study procedures. Participants will also be excluded if they have (i) known hypersensitivity or intolerance to blackcurrants or berry fruit-derived products, (ii) health conditions that may affect their ability to regulate sugar digestion/absorption (i.e. diabetes, metabolic syndrome). In addition, participants will be excluded if they are pregnant or planning to get pregnant in the near future or have any of the following conditions: (i) blood borne diseases (e.g. hepatitis), (ii) clinically diagnosed high/low blood pressure, (iii) recent bacterial or vial illness, (iv) are taking any mediation that affects the properties of blood (e.g. blood clotting). Furthermore, potential volunteers will be excluded if they have donated blood within 4 weeks from the start of the study.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026