The Melanoma Genomics Managing Your Risk Study: examining the impact of personal melanoma genomic risk information on prevention behaviours in the general population

Participants randomly allocated to the intervention arm will receive: 1. A mailed saliva collection kit for subsequent DNA extraction and genotyping. 2. Personal genetic risk of melanoma information. About 2-3 months after providing a saliva sample, participants will receive their genetic risk information in a hardcopy booklet sent via postal mail. The booklet, developed as part of our pilot trial (ACTRN12615000356561), presents and describes participants’ individual genetic risk of melanoma using evidence-based risk communication strategies, such as numerical and visual presentations of lifetime absolute risk. Participants reported high satisfaction with the genetic risk booklet in the pilot trial, and we have made minor modifications to enhance clarity for participants in the Managing Your Risk Study. The risk information includes: *An absolute risk percentage showing their remaining lifetime risk of developing melanoma. For example, our pilot study observed remaining lifetime genomic risk estimates of up to 20% but the average risk was around 2-4%. * A risk level: higher than average = top 25% of genomic risk, average = middle 50%, lower than average = bottom 25%; based on quartile cut-points within each age, sex and state strata. The genetic risk booklet also contains simple explanatory information about how a person’s risk is calculated, and what they can do to reduce their risk. 3. A telephone call from the study genetic counsellor. The genetic counsellor will contact all participants in the intervention arm within two-weeks after their genetic risk information is sent via postal mail. The purpose of the phone call is to confirm receipt of the booklet and to answer any potential questions. We expect the phone call will last approximately 10 minutes, depending on the number of questions or discussion points raised by participants. 4. An educational booklet on melanoma preventive behaviours and skin examinations. The educational booklet, developed for our pilot trial (ACTRN12615000356561), is based on SunSmart campaign resources. It includes information on risk factors for melanoma and other skin cancers, recommendations for optimal sun exposure and sun protection behaviours, information about skin examinations including an online video showing step-by-step skin self-examination, and information about Vitamin D. Educational materials are widely used by the Australian general public and, as such, are considered ‘standard care’. In the pilot trial, this educational booklet was rated highly (more than 8 out of 10) in terms of satisfaction by participants.