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Tissue oxygen saturation change on upper extremities after ultrasound guided infraclavicular brachial plexus blockade.

Tissue oxygen saturation change on upper extremities after ultrasound guided infraclavicular brachial plexus blockade; Prospective observational study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12617000688381
Acronym
TOUGIB
Enrollment
40
Registered
2017-05-12
Start date
2017-05-22
Completion date
2017-06-26
Last updated
2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Several methods were studied for objective assessment of the peripheral nerve block. The aim of the study will investigate whether tissue oxygen saturation (StO2), a measure of the proportion of oxygenated haemoglobin relative to total haemoglobin level in the tissue, is a reliable and objective method for assessing the adequacy of infraclavicular blockade and to describe the time course of StO2 changes once peripheral nerve block has been achieved during surgery. The InSpectraTM tissue spectrometer (Hutchinson technology, Hutchinson, MN, USA) is a novel non-invasive haemodynamic monitor. It utilises near infra-red spectroscopy (NIRS) technology to measure the proportion of oxygenated haemoglobin relative to total haemoglobin level in the tissue In this study, StO 2 will measure in 40 patients schedule for elective hand surgery under infraclavicular nerve block. Non-invasive StO 2-monitoring (InSpectraTM StO 2, Hutchinson Technology Inc., Hutchinson, Minnesota, USA) will use in patients before ultrasound guided infraclavicular plexus blockade and during the first 30 minute of the blockade in both hands. The StO 2 sensor will be place on the thenar muscle of the right hand in a position, which ensured an adequate total haemoglobin index (THI) of more than 5.0 according to the manufacturer recommendation. To measure tissue oxygen saturation near-infrared light (680–800 nm) is emitted into the thenar tissue with a depth of about 15 mm. In the light that is reflected from the tissue, the percentage of oxygenated haemoglobin is calculated by using the different absorption spectra of oxygenated and deoxygenated haemoglobin.

Interventions

Several methods were studied for objective assessment of the peripheral nerve block. The aim of the study will investigate whether tissue oxygen saturation (StO2), a measure of the proportion of oxygenated haemoglobin relative to total haemoglobin level in the tissue, is a reliable and objective method for assessing the adequacy of infraclavicular blockade and to describe the time course of StO2 changes once peripheral nerve block has been achieved during surgery. The InSpectraTM tissue spectro

Several methods were studied for objective assessment of the peripheral nerve block. The aim of the study will investigate whether tissue oxygen saturation (StO2), a measure of the proportion of oxygenated haemoglobin relative to total haemoglobin level in the tissue, is a reliable and objective method for assessing the adequacy of infraclavicular blockade and to describe the time course of StO2 changes once peripheral nerve block has been achieved during surgery. The InSpectraTM tissue spectrometer (Hutchinson technology, Hutchinson, MN, USA) is a novel non-invasive haemodynamic monitor. It utilises near infra-red spectroscopy (NIRS) technology to measure the proportion of oxygenated haemoglobin relative to total haemoglobin level in the tissue StO 2 was measured in 40 patients schedule for elective hand surgery under infraclavicular nerve block. Non-invasive StO 2-monitoring (InSpectraTM StO 2, Hutchinson Technology Inc., Hutchinson, Minnesota, USA) will use in patients before ultrasound guided infraclavicular plexus blockade and during the first 30 minute of the blockade in both hands. The StO 2 sensor will be place on the thenar muscle of the right hand in a position, which ensured an adequate total haemoglobin index (THI) of more than 5.0 according to the manufacturer recommendation. To measure tissue oxygen saturation near-infrared light (680–800 nm) is emitted into the thenar tissue with a depth of about 15 mm. In the light that is reflected from the tissue, the percentage of oxygenated haemoglobin is calculated by using the different absorption spectra of oxygenated and deoxygenated haemoglobin. infraclavicular blocks will perform using a 22-gauge stimulating needle under US guidance (Esaote My Lab 30 US gold machine, Florence, Italy) using in-plane approach. The blocked and non-blocked arms will compare at precisely timed intervals. However, the duration of sensory block, the duration of motor block, side effects and complications Bromage scale for motor block and Pinprick test in the sensory block will be recorded.

Sponsors

Harran University School of Medicine, Research and Training Hospital
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

Patients undergoing elective upper limb surgery with ASA physical status I or II, aged between 18 and 65 years

Exclusion criteria

contraindication to regional anesthesia, preexisting peripheral vascular disease or diabetes, an allergic reaction to local anesthetics and use of medications such as a- and b-blocking drugs.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026