None listed
Conditions
Brief summary
Myocardial infarction (‘Heart attack’) remains a significant cause of morbidity and mortality. Despite re-opening blocked heart arteries, there is still a group of patients that have a worse outcome due to disease of smaller arteries, not visible with conventional diagnostic x-ray imaging. A tool that directly measures involvement of the smaller arteries at the time of the initial heart attack would therefore be desirable. The index of microvascular resistance is such a technique that uses a special pressure wire to look at changes in flow in heart arteries in order to calculate resistance within the smaller vessels. We plan to use this tool in patients with heart attacks to assess the small vessel (microcirculatory) involvement. We will also take a small amount of blood to look at specific blood tests that show degrees of inflammation and the function of blood cells. The blood sample will be stored in -80C freezer for various inflammatory markers tests at a later stage. We will also assess the effect of medications given for heart attacks on the small blood vessel function. The goal of this study is to investigate factors that influence the function of the small blood vessels. We will utilise this technique in order to improve treatment for all patients who have a heart attack and improve our understanding of the disease process and ultimately provide new treament options that may benefit the Australian community.
Interventions
Coronary microvessel function is evaluated in patients who undergo percutaneous coronary stenting. Index of microvascular resistance (IMR) represents microvascular function and is derived from measurements taken using a pressure-temperature sensor-tipped wire. These measurements are taken before and after coronary stents are deployed. The procedure is performed by the treating interventional cardiologist. Blood samples are collected to measure the inflammatory markers. Patient demographics and p
Coronary microvessel function is evaluated in patients who undergo percutaneous coronary stenting. Index of microvascular resistance (IMR) represents microvascular function and is derived from measurements taken using a pressure-temperature sensor-tipped wire. These measurements are taken before and after coronary stents are deployed. The procedure is performed by the treating interventional cardiologist. Blood samples are collected to measure the inflammatory markers. Patient demographics and procedural characteristics data are collected.
Sponsors
St Vincent's Hospital Melbourne
Study design
Allocation
Non-randomised trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patients who present to hospital with evidence of coronary artery disease and undergo coronary intervention.
Exclusion criteria
Patients are excluded if they have active inflammatory/autoimmune disorders, previous history of myocardial infarction or PCI of the culprit vessel in the previous 12 months, previous coronary artery bypass graft surgery, severe renal impairment (eGFR <30ml/min), severe left ventricular dysfunction (ejection fraction <35%), contraindication to prolonged dual antiplatelet therapy, and significant valvular heart disease.
Outcome results
None listed