None listed
Conditions
Brief summary
The aim of this 15-year follow-up study was to determine the influence of environmental, anatomical, metabolic, physiological and genetic determinants on health outcomes in older women. This was a follow-up study of 1500 women aged 70 years and over, recruited from the general population of Perth, Western Australia.
Interventions
Baseline and longitudinal measurements of phenotypic data related to the health of older women including environmental factors (e.g. dietary intakes, physical activity), anatomical measures (e.g. bone mass and structure, anthropometry, body composition, carotid intimal medial thickness), physiological function (e.g. mobility, muscle strength), metabolic function (e.g. ApoE levels, hormonal status, homocysteine, beta-amyloid), and genetic polymorphisms (e.g. estrogen receptor, TGF beta, ApoE 4, C
Baseline and longitudinal measurements of phenotypic data related to the health of older women including environmental factors (e.g. dietary intakes, physical activity), anatomical measures (e.g. bone mass and structure, anthropometry, body composition, carotid intimal medial thickness), physiological function (e.g. mobility, muscle strength), metabolic function (e.g. ApoE levels, hormonal status, homocysteine, beta-amyloid), and genetic polymorphisms (e.g. estrogen receptor, TGF beta, ApoE 4, Cyp19, MTHFR). The duration of observation was from 1998 to 2013. All participants were initially recruited in 1998 to a 5-year randomised controlled trial, the Calcium Intake Fracture Outcome Study (trial ID ACTRN12615000750583). Participants were then enrolled for an additional 10-year follow-up study (2003-2013).
Sponsors
University of Western Australia
Eligibility
Sex/Gender
All
Age
70 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
The key inclusion criteria was age greater than 70 years and less than or equal to 85 years, and likelihood to survive a 5-year study. This key inclusion criteria was for all participants previously enrolled in the Calcium Intake Fracture Outcome Study (trial ID ACTRN12615000750583).
Exclusion criteria
Receipt of a bone active agent. This exclusion criteria was for all participants previously enrolled in the Calcium Intake Fracture Outcome Study (trial ID ACTRN12615000750583). There were no other specific exclusions so that the results could be generalized to the entire ambulant population.
Outcome results
None listed