Adrenal cortical response during Extracorporeal membrane oxygenation.

Adrenal cortical response during Extracorporeal membrane oxygenation in children and adults admitted to Intensive Care.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12617000629336

Enrollment

100

Registered

2017-05-01

Start date

2017-05-15

Completion date

2018-06-30

Last updated

2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a single center prospective observational study on adreno-cortical changes during critical illness in children and adults. The aim is to elucidate if the diurnal changes in serum cortisol is impared during critical illness in all ages, both in ECMO but also in pediatric intensive care patients. Concerining the adult population we will also perform a Synacthen test on Day 3. Secondary aims are ICU and survival over the longer run (All cause mortality at 1, 3 and 5 years).

Interventions

Serum-cortisol and Cortisol binding globulin will be assessed three times dialy on day 1, 2, 5, 10, 20, 30, etc. in all ages. For adult patients a Synacthen test will be performed day 3. The investigation continues till the patient is discharged from the ICU.

Eligibility

Sex/Gender

All

Age

No minimum to 78 Years

Healthy volunteers

Inclusion criteria

Consecutive patients admitted to the PICU or ECMO ICU at Karolinska University Hospital, expected to stay at least 48 hours in any of these ICU:s, and not on high-dose cortico steroids.

Exclusion criteria

Moribund, or patients not expected to stay in the Intensive care unit for more than 48 hours, or pateints on high-dose cortico steroids.

Outcome results