None listed
Conditions
Brief summary
In order to describe lactate metabolism in critically ill patients our group has designed a simple, minimally invasive protocol in healthy volunteers. In our current study we aim to use this protocol in a mixed ICU population. Briefly patients will be recruited after informed consent (from next of kin when appropriate). After this baseline samples will be drawn and a bolus dose of 13C-labeled lactate (2.7mg/kg) will be given. Blood samples will be drawn over two hours (no more than 100 ml all together), samples will be frozen and analyzed for lactate concentration and 13C-enrichment. An interim analysis will be conducted after the first 6 patients. Data will be collected from electronical charting systems.
Interventions
Each ICU patient will receive a single bolus dose of 13C-labeled lactate (2.7mg/kg body weight). Existing arterial and venous lines will be used. Blood samples will be drawn at t=0 and then every two minutes during the first hour and every fifth minute for the second hour (t=2,4,6...56,58,60,65,70...110,115,120)
Sponsors
Karolinska University Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
- Patients treated in the ICU who have an existing, functioning arterial and venous lines - Informed consent to participate (can be given by next of kin when appropriate)
Exclusion criteria
Unwillingness to participate, Unable to obtain informer consent. Terminal liver insufficiency.
Outcome results
None listed