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Can High Intensity Interval Training improve fitness before major abdominal surgery?

High Intensity Interval Training to optimise fitness before major abdominal surgery. Can High Intensity Interval Training improve preoperative fitness and postoperative outcomes?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617000587303
Enrollment
63
Registered
2017-04-26
Start date
2015-09-08
Completion date
2018-09-19
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Many of the risk factors associated with developing complications after surgery cannot be changed, such as the extent of the problem requiring surgery, the operation required and the health problems that the patient suffers from. However it may be possible to reduce complications by optimising fitness before surgery. In this study we will examine if fourteen exercise sessions on an exercycle over five weeks can improve overall cardiorespiratory fitness. Fitness will be measured by the peak oxygen consumption, which is measured by cardiopulmonary exercise testing. We will also monitor patients after surgery to check for differences in a range of clinical outcomes including the speed of recovery from surgery, length of hospital stay, complications and quality of life. Both the individual and the community may benefit from this research. Improving fitness, and potentially improving outcomes will be of benefit to the individual patient. At the community level there is no work being routinely done to improve fitness before surgery. If we demonstrate that improving fitness improves operative outcomes this should lead to the introduction of exercise programs for patients while they are waiting for their surgery.

Interventions

Patients will be randomised to 'standard care' or to the intervention. The intervention is a supervised preoperative fitness program. This program will involve 14 sessions of High Intensity Interval Training on a cycle ergometer over 4-6 weeks prior to surgery. The aim is to perform three sessions a week, but depending on the number of available days between enrolment in the study and the date of surgery four sessions a week may be performed. Exercise will be performed with other patients who a

Patients will be randomised to 'standard care' or to the intervention. The intervention is a supervised preoperative fitness program. This program will involve 14 sessions of High Intensity Interval Training on a cycle ergometer over 4-6 weeks prior to surgery. The aim is to perform three sessions a week, but depending on the number of available days between enrolment in the study and the date of surgery four sessions a week may be performed. Exercise will be performed with other patients who are enrolled in the same or similar studies under the supervision of a senior trained exercise physiologist (greater than five years experience) in the School of Physical Education. Exercises will use stationary cycling (Monark cycle ergometers), with monitoring of pulse and blood pressure. For patients on beta blockers the level of perceived exertion, using the 1-20 Borg scale will be monitored as well as the pulse. Each session will begin and end with 5 min of unloaded cycling. Initial sessions will include ten 15-second intervals at a heart rate exceeding 85% of age predicted maximum heart rate, or a rating of perceived exertion (RPE) score of 16, with ‘rest’ intervals of 45 seconds at heart rates of 50% maximum heart rate. All training programs will be individualised to meet the capacity of the participant. The duration of exercise will increase and the duration of rest will decrease as the participant gains fitness. The aim of the 14 session format is for participants to achieve five 2 minute intervals of high intensity work with 2 minute active rest durations. The total interval duration will not exceed 10 minutes throughout the training period. Each session will last approximately 20 to 25 minutes.. For safety reasons, the intensity of exercise and intervals will be adjusted if systolic blood pressure exceeds 180 mm Hg, if the heart rate exceeds 95% of the maximum observed on baseline CPET, or if the perceived exertion on the Borg scale exceeds 18. Pulse (as the indicator of ‘high intensity’) will be monitored and recorded from downloadable Polar Heart Rate monitors to assure exercise adherence. This will be monitored by the exercise physiologist and the duration of the training intervals will be adjusted to reach the required heart rate. Monitoring for adherence will look at the number of sessions attended and the number of sessions where the target heart rate is reached. Patients who have their surgery delayed will complete one additional HIIT session per week up until surgery to maintain fitness. All adverse events will be recorded.

Sponsors

Dr John Woodfield
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
45 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

Patients about to undergo major abdominal surgery. Major abdominal surgery includes any laparotomy. It does not include laparoscopic cholecystectomy or appendicectomy or TURP. It does include abdominal rectal prolapse surgery, nissan fundoplication, and abdominal hysterectomy. It also includes any procedures considered to be more major, in terms of their potential impact on the patient, than the above procedures. There needs to be sufficient time to perform the preoperative exercise (enrolment needs to be approximately five weeks before surgery) and the participant needs to live close enough to the hospital to be able to attend the exercise sessions.

Exclusion criteria

1) Inability to exercise or to perform a CPET 2) Uncontrolled hypertension (BP>180/100) 3) Experiencing clinical angina (Does not include those who are asymptomatic on Rx or those who have had successful revascularization) 4) Myocardial infarction in the past 3/12 5).Uncontrolled cardiac arrhythmias 6) Intracranial aneurysm 7) Aortic aneurysm >6.5cm 8) Severe obstructive pulmonary disease with a FEV1 < 1 litres 9) Inability to provide consent 10) Significant anaemia, Hb <80g/l 11) Short course preoperative radiotherapy 12) Preoperative chemotherapy

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 6, 2026