None listed
Conditions
Brief summary
Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum (B ranarum). The synonym “Basidiobolomycosis” is given to diseases caused by Basidiobolaceae which is a family coming under entomophthorales which is a subdivision of Zygomycetes. B. ranarum was first described in 1886 and was isolated from frogs. It has been found in decaying vegetation, foodstuffs, fruits, and soil. It is also excreted from the gastrointestinal tracts of reptiles, amphibians, fish, and insectivorous bats. The organism B ranarum may be found all over the world but Basidiobolomycosis is most commonly reported from tropical and subtropical areas of the world. It typically causes a subcutaneous disease of arms, trunks and buttocks. The mode of transmission is assumed to be minor skin trauma and insect bites. Extracutaneous Basidiobolomycosis is rare, however, it has been reported in lungs, retroperitoneum and gastrointestinal system. Iatrogenic causes of infections, like needle transmission, has also been suggested by some authors. The disease may be transmitted by inhalation, by the soil, water and vegetation that is contaminated with animal feaces. Gastrointestinal basidiobolomycosis (GIB) is considered to be a rare type of mycosis that is characteristically being reported in immunocompetent rather than immunocompromised patients. The first presumed case of GIB was reported in a 6 year old Nigerian boy in 1964 while the first culture proven case was diagnosed in 1986 in USA. During the last 30 years the reported cases were diagnosed mainly from arid desert region of USA and from Middle Eastern countries especially Saudi Arabia. Clinically, gastrointestinal basidiobolomycosis may mimic malignancy, inflammatory bowel disease or chronic infections like tuberculosis. Due the rarity of the disease and its wide spectrum of presentations, high index of suspicion may be required for accurate diagnosis. Serological tests and histopathological findings can help in diagnosing the condition, nevertheless, the most definitive diagnostic tool is culture. Among all GIB reported cases, colon is the most common organ involved and may reach up to 82% of the affected organs in some reports. Moreover, surgical intervention is required in most of these cases. In this study we are reviewing the clinical presentations, indications and surgical outcomes of all patients who were diagnosed and treated from colonic basidiobolomycosis in the last 10 years in Aseer Central Hospital, A tertiary referral hospital in the southern region of Saudi Arabia.
Interventions
patients with basidiobolomycosis of the colon were subjected to colectomies followed by receiving antifungal treatment for 1-2 years as the standard care of their treatment. Patients were followed up regarding recurrence of symptoms or development of recurrence in any other organ for one year after colectomies. Data were retrieved from patients files.
Sponsors
King Khalid University
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Healthy volunteers
No
Inclusion criteria
all patients who were diagnosed as colonic Basidiobolomycosis and required surgical intervention during the last 10 years (2006 – 2016) in Aseer Central Hospital. Colonic affection was defined as microscopic or macroscopic involvement of the colon or the rectum preoperatively by imaging or colonoscopy or intra-operatively by observation.
Exclusion criteria
Patients less than 10 years are treated by pediatric department. Patients with colonic basidiobolomycosis who were treated conservatively were excluded from the study
Outcome results
None listed