None listed
Conditions
Brief summary
Sadly, children who undergo cardiac surgery as infants are at increased risk of learning difficulties as they grow older. Why this occurs is not known and white matter injury detected on specialised brain scans is considered to be the crucial link. This study will look at the relationship between blood pressure during, and after, cardiac surgery as the potential link. The study will also assess the critical blood pressure threshold to avoid injury as currently there is no published data to inform clinical practice. The impact of this research: Preventing brain injury may not only improve neurodevelopmental outcomes in the growing population of ‘heart kids’ in New Zealand but also decrease the significant educational, economic and societal burden created by this potentially avoidable consequence of critical cardiac surgery.
Interventions
Brain MRI before cardiac surgery and approximately 5-10 days after cardiac surgery depending on availability of MRI scanner and paediatric cardiac anaesthetist.
Arterial blood pressure will be monitored invasively with an invasive arterial line.
Sponsors
Starship Children's Hospital
Eligibility
Sex/Gender
All
Age
0 to 4 Weeks
Healthy volunteers
No
Inclusion criteria
Infants less than 4 weeks of age undergoing elective cardiac surgery with cardiopulmonary bypass at Starship Children's Hospital.
Exclusion criteria
1. Less than 36 weeks gestation 2. Multiple congenital abnormalities 3. Recognisable genetic or malformation syndrome associated with abnormal neurolodevelopment 4. History of maternal or congenital infection 5. History of birth asphyxia or cardiac arrest 6. A history of stroke or intracranial bleeding
Outcome results
None listed