The value of liver elastography measurements using endoscopic ultrasonograpy in patients with chronic viral hepatitis B, C and nonalcoholic steatohepatitis.

The value of measuring the liver stiffness using endoscopic ultrasonograpy in patients with chronic viral hepatitis B, C and nonalcoholic fatty liver disease.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12617000448347

Enrollment

100

Registered

2017-03-27

Start date

2017-03-01

Completion date

2019-03-01

Last updated

2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Endoscopic ultrasound (EUS) is a good tool for real-time visualization of the left liver lobe and it has a software to measure the liver elastography which shows the stiffness of the liver. The comparison of EUS-liver elastography and liver biopsy parameters of inflammation and fibrosis is not known. Although EUS is an invasive endoscopic procedure, it has unique beneficial role for the evaluation of subepithelial masses of gastrointestinal tractus such as esophageal varices, common bile duct anomalies such as stones, pancreatic cysts, mediastinal masses....etc. During EUS examination for any indication, the operator can easyly evaluate the liver and can add the liver stiffness findings to the report. This study aims to prospectively evaluate the value of EUS-liver elastographic measurements in patients with chronic hepatitis B, C and nonalcoholic fatty liver disease who were referred to EUS for other indications. The patients who have biopsies in the last 2 years of the EUS-examination will be compared by their EUS- elastography findings and biopsy findings. There will be a control group who have no known positivity for viral hepatitis serology and no liver disease.

Interventions

Endoscopic ultrasound (EUS)-The patients refered to EUS examination for regular etiologies such as pancreatic cysts, subepithelial lesions, investigation of common bile duct Stones etc will be examined for hepatic parenchymal stiffness using the software for elastography measurement that is already available with the device. This procedure will add only 2-3 minutes to the EUS examination. A seperate and dedicated EUS session will not be planned for the whole patient groups. Those having accompa

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

All patients who are referred to endoscopic ultrasound examination and who accept the hepatic elastograpgy measurements to be obtained during this examination.

Exclusion criteria

Patients with -hepatocellular carcinoma -hepatic metastasis -liver disease other than chronic viral hepatitis B, C or nonalcoholic steatohepatitis (suc as autoimmune hepatitis,, sclerosing cholangitis, wilson's disease,, pheochromatosis, noncirrhotic portal hypertension.

Outcome results