Validation of head injury prognostic calculators

Comparative study of two tools in determining severe head injury outcomes in an Australian setting: CRASH (Corticosteroid Randomisation after Significant Head injury) versus IMPACT (International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12617000382370

Enrollment

256

Registered

2017-03-14

Start date

2011-01-01

Completion date

2016-12-31

Last updated

2018-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Head injury is common, affecting Australians at a rate of 107 per 100,000 people. Its outcome varies from complete recovery to disability. Two recognised tools predict these outcomes, based on presentation: CRASH (Corticosteroid Randomisation after Significant Head injury) and IMPACT (International Mission for Prognosis and analysis of Clinical Trials in TBI (Traumatic Brain Injury)). Clinical studies independently validated them. One reported study compared them within a non-Australian community. Study Aim: To compare CRASH’s efficacy against IMPACT in predicting severe head injury outcomes. Research design: -Recruiting severe head injury patients admitted to Princess Alexandra Hospital as participants. -Collect symptom details from first admission and after six months. -Calculate participants’ CRASH and IMPACT scores and compare with actual outcomes. Reviewing participants after six months provides information relating initial presentation to recovery. The results would identify whether CRASH or IMPACT better predicts outcomes. This knowledge may influence future patient care and research.

Interventions

CRASH (Corticosteroid Randomisation After Significant Head Injury) -This prognostic model may be used as an aid to estimate mortality at 14 days and death and severe disability at six months in patients with traumatic brain injury (TBI). The predictions are based on the average outcome in adult patients with Glasgow coma score (GCS) of 14 or less, within 8 hours of injury, and can support clinical judgment. -Duration of observation of each participant is 6 months (from admission to 6 months po

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

The inclusion criteria consists of participants with severe head injury requiring intubation (i.e. Glasgow Coma Scale <8).

Exclusion criteria

The exclusion criteria consists of previously physically or mentally disabled participants (in order to maintain uniformity in outcome).

Outcome results