None listed
Conditions
Brief summary
This research study which will investigate the effect of continuous positive airway pressure (CPAP) treatment on brain wave activity recorded using high density electroencephalography (EEG) in patients diagnosed with moderate to severe obstructive sleep apnea. The study will examine changes in sleep and wake brain activity profiles and how these may relate to neurobehavioural function including memory following CPAP treatment.
Interventions
Patients with a confirmed diagnosis of OSA will undergo overnight sleep study (polysomnography, PSG) with simultaneous high density EEG recordings of brain activity before and after 3 months of continuous positive airway pressure (CPAP) treatment. CPAP is the current gold-standard treatment for OSA. Participants will follow the routine clinical care pathway: this includes 1) mask fitting and CPAP education session in the afternoon followed by an overnight in-lab CPAP titration study that night,
Patients with a confirmed diagnosis of OSA will undergo overnight sleep study (polysomnography, PSG) with simultaneous high density EEG recordings of brain activity before and after 3 months of continuous positive airway pressure (CPAP) treatment. CPAP is the current gold-standard treatment for OSA. Participants will follow the routine clinical care pathway: this includes 1) mask fitting and CPAP education session in the afternoon followed by an overnight in-lab CPAP titration study that night, then follow up care with the CPAP Educator to monitor adherence either in person or over the phone during the treatment period approximately at weeks 2, 6 and 12 weeks after initiating treatment . No parameters of the treatment are determined based on participation in this study. Study participants undergo CPAP treatment as prescribed by their treating physician .
Sponsors
Woolcock Institute of Medical Research
Eligibility
Sex/Gender
Male
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
A diagnosis of moderate OSA defined by an apnea-hypopnea index (AHI) of greater than 15/hr as measured by PSG and confirmed by sleep physician. Participants must be recommended for CPAP treatment by their treating physician and be willing to commence 3 months of CPAP use. Participants must fluent in English and also have the ability to perform neurobehavioural tests and provide informed consent.
Exclusion criteria
Clinically significant co-morbidity; history of head injury or psychiatric/neurological disorder (including stroke); use of CNS active agents; heavy alcohol consumption (40g daily); current shift-worker or travelled overseas within the last 2 weeks; previously used CPAP.
Outcome results
None listed