None listed
Conditions
Brief summary
In order to study lactate kinetics in ICU patients with a minimally invasive technique we are performing this pilot study on healthy volunteers. After a standard health form, medical examination and testing the fasting subjects will receive venous and arterial catheters. Base line samples are drawn and frozen. A bolus of stable isotopically labeled 13C-lactate will be given (2.7mg/kg body weight). Blood samples will be drawn at 37 time points throughout 2 hours (not more than 100ml blood al together). Samples will be analyzed at bedside analyzer and snap frozen for later analysis for relationship between 13C-labelled and normal lactate. Subjects will monitored with ECG, pulsoximetry and blood pressure throughout the experiment.
Interventions
Healthy volunteers will receive a peripheral venous catheter and an arterial catheter. They will then receive a bolus of 13-labelled lactate (2.7mg/kg) and blood samples will be drawn continuously during the next two hours (not more than 100ml blood will be drawn).
Sponsors
Karolinska University Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Healthy volunteers without ongoing mediaction
Exclusion criteria
Abnormalities on lab screening, including pregnancy test
Outcome results
None listed