None listed
Conditions
Brief summary
to determine whether in normal healthy volunteers without recent antibiotic exposure, one month of daily erythromycin treatment will induce lower rates of macrolide resistance in commensal oropharyngeal flora than one month of daily azithromycin
Interventions
60 participants will be recruited and randomly assigned to receive either azithromycin (125mg) twice per day or Erythromycin ethylsuccinate 400mg twice per day for 4 weeks orally. adherence to therapy will be monitored by counting the number of tablets retuned after one week and 4 weeks. 80% adherence to therapy will be considered compliant.
Sponsors
Mater misericordiae Ltd, South Brisbane
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Consenting individual Non-smoker Nil antibiotics for 3 months prior to study enrolment; no macrolide antibiotic for 12 months Nil current illness Ability to provide a consenting close cohabitant Cohabitant defined as someone who has more than 4 hours of interaction with the index case on at least 5 days per week
Exclusion criteria
Smoking Chronic lung disease including asthma if on corticosteroids Use of any antibiotic within the preceding 3 months Use of any Macrolide antibiotic within the preceding 12 months Current use of any antibiotic Respiratory tract illness within the preceding 1 month current respiratory tract illness
Outcome results
None listed