The efficacy of intravenous ibuprofen and pregabalin before laparoscopic cholecystectomy surgery on postoperative pain.

Comparison of pregabalin and pregabalin+ intravenous ibuprofen for preemptive (before the procedure) analgesia for laparoscopic cholecystectomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617000260325

Enrollment

Registered

2017-02-20

Start date

2016-11-01

Completion date

Unknown

Last updated

2017-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

For managing acute postoperative pain, New medical treatments administered preoperatively. For this purpose, pregabalin has been used previously for laparoscopyc cholecystectomy surgery in some clinical research. Intravenous ibuprofen ( NSAID analgesic) used until 2009. We want to investigate the effect of pregabalin+intravenous ibuprofen used before the operation preemptively on postoperative analgesia for laparoscopyc cholecystectomy. We enroll 58 patients who undergone elective laparoscopyc cholecystectomy surgery. Exclusion criteria; emergency cholecystectomy, antiepileptic drug use, allergic reaction for study drugs, ASA III-IV patients. mild or severe renal insufficiency. Group Pregabalin: 1 hour before operation patients will take 150 mg pregabalin oral form. Group Pregabalin + intravenous ibuprofen: 1 hour before operation patients will take 150 mg pregabalin oral form. Additionally 1/2 hour before operation patients will take 800 mg intravenous ibuprofen. After operation we give patient controlled analgesia contains fentanyl, and we will evaluate postoperative pain and patient satisfaction.

Interventions

For postoperative pain we will give one group of patients ( 29 patients for each group) pregabalin 150 mg oral form 1 hour before the operation. The other group will take pregabalin like group 1 and intravenous ibuprofen 800 mg, 1/2 hour before the operation.

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

ASA ( american society of anesthesiologists) Physical Status 1-2, planned for elective laparoscopyc cholecystectomy

Exclusion criteria

Emergency cholecystectomy. Antiepileptic drug use, ASA 3 patient groups, Mild or severe renal insufficiency

Outcome results