None listed
Conditions
Brief summary
The objective of current study is to answer the question, Do the mydriatic eye drops used prior fundus examination in preterm infants affect cerebral blood flow ?.Mydriatic eye drops causing pupil dilatation have systemic vasoconstriction effects on different blood vessels in the gut, kidneys, and lungs. Studying the effects of routine NICU medications on cerebral blood flow is of paramount importance particularly preterm infants.
Interventions
Impact of mydriatic eye drops on neonatal cerebral blood flow.
-Fundus examination following installation of mydriatics is a routine practice in neonatal intensive care unit (NICU) for retinopathy of prematurity ( ROP ) examination, the purpose of this study is to evaluate any possible effect of mydriatic eye drops on cerebral blood flow of preterm infants.
-We will prospectively study 50 preterm neonates admitted to NICU, Dubai hospital with a mean gestational age of 28 weeks (range 24-30 we
Impact of mydriatic eye drops on neonatal cerebral blood flow. -Fundus examination following installation of mydriatics is a routine practice in neonatal intensive care unit (NICU) for retinopathy of prematurity ( ROP ) examination, the purpose of this study is to evaluate any possible effect of mydriatic eye drops on cerebral blood flow of preterm infants. -We will prospectively study 50 preterm neonates admitted to NICU, Dubai hospital with a mean gestational age of 28 weeks (range 24-30 weeks ), birth weight (range 0.5 -2 kgm) at the post-conceptional age of 33 weeks, color Doppler flow study carried out immediately before and then one hour after installation of mydriatic eye drops for ROP examination . We will investigate the peak systolic velocity(PSV), end diastolic velocity(EDV) and resistive index (RI)in both anterior and middle cerebral arteries as well as blood pressure, heart rate, respiratory rate, pain score and oxygen saturation Spo2. -To attain the maximal and sustained mydriasis for proper fundus examination, at least two drugs are used namely phenylephrine hydrochloride 2.5% and tropicamide 0.5% eye drops. Phenylephrine has an alpha sympathomimetic agonist effect, readily absorbed from mucosa with an excessive vasopressor systemic response. -The present investigation was designed to study the possible systemic effects of mydriatic eye drops-used for ROP examination- on cerebral blood flow in preterm babies. -Cerebral blood flow measurements : All Pulsed-wave Doppler ultrasound studies to be performed by the same investigator (AA).Using Philips HD11XE (Philips Medical Systems, Eindhoven, The Netherlands).and a convex transducer (4-8MHz) in a quiet room. 15 cerebral blood flow velocity( CBFVs) records will be randomly selected and to be revised later by a radiologist who was blinded to the study to eliminate bias. This protocol to be repeated two times for each patient, once before application of eye mydriasis and then an hour after ROP examination. we will record the vital data for the babies namely heart rate ,SPO2, blood pressure , temperature and pain score again before and after the procedure.
Sponsors
ATEF ALSHAFEI
Eligibility
Sex/Gender
All
Age
3 Weeks to 12 Weeks
Healthy volunteers
No
Inclusion criteria
Preterm infants with gestational age at birth of 24 to 30 weeks admitted to NICU, Dubai hospital who are vitally stable at time of enrollment.
Exclusion criteria
1- Major congenital anomalies and known syndromes. 2-Hemodynamically significant patent ductus arteriosus PDA. 3- Congenital or acquired hydrocephalus. 4- infants on inotropic support.
Outcome results
None listed