None listed
Conditions
Brief summary
Anthocyanins are compounds found naturally in fruits and vegetables that provide the rich colour such as blue and deep red. These compounds possess strong antioxidant abilities which may protect the cells of the body from damage. Over recent years, there has been considerable interest in the health effects of diets that are high in plant foods, and particularly the role of anthocyanin content of foods. There is some research that has shown that intake of foods and beverages that are rich in anthocyanins may protect against age-related diseases, such as cancer, cardiovascular disease and neurodegeneration. The purpose of this study is to determine the effect of consumption of fruit juice for 8 weeks on blood pressure and memory and cognition in generally healthy older adults. The study will also determine if the fruit juice affects inflammatory markers in the blood (these are produced as the body's response to injury or infection) and change in gut microbiota population.
Interventions
A randomised, double-blind, controlled, crossover trial will be conducted. Consenting participants will be randomly allocated to either an intervention (Queen Garnet Plum juice) or a control arm (blackcurrant flavoured cordial) by independently computer-generated block randomisation. All researchers will be blinded to the allocation order and encoding broken after data analysis.
Intervention: Each arm will last for eight weeks with a 4-week washout period in between, and thereafter allocation.
A randomised, double-blind, controlled, crossover trial will be conducted. Consenting participants will be randomly allocated to either an intervention (Queen Garnet Plum juice) or a control arm (blackcurrant flavoured cordial) by independently computer-generated block randomisation. All researchers will be blinded to the allocation order and encoding broken after data analysis. Intervention: Each arm will last for eight weeks with a 4-week washout period in between, and thereafter allocation. Participants will receive 200mL/day of QGP juice (intervention arm) or commercially available blackcurrant cordial (control arm). Beverages will be delivered to participants homes weekly, in opaque plastic bottles. The QGP fresh fruit will be provided in-kind by Nutrafruit Pty Ltd and the juice produced and bottled by Department of Agriculture Fisheries and Forestry, Queensland, using a novel method to retain the bioactives. Unconsumed juice will be collected for compliance, and urinary biomarker metabolites assessed.
Sponsors
Karen Charlton
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
55+ years Healthy
Exclusion criteria
1. Uncontrolled hypertension (Blood Pressure: >160/95 on day of testing) 2. Dementia (any level) 3. Any fruit allergies 4. Type 1 (Insulin dependent) diabetes 5. Any other unstable physical or mental health condition 6. Have difficulty swallowing.
Outcome results
None listed