The effects of magnesium on blood vessel function

Effects of a diet that includes consuming a magnesium supplement on endothelial function

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12617000160336

Acronym

None

Enrollment

Registered

2017-01-30

Start date

2017-02-13

Completion date

2017-06-30

Last updated

2017-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Heart disease is a major cause of death and disability in Australia. We have already shown that diet has a key role to play in maintaining blood vessel health. A low magnesium diet is emerging as a risk factor for heart disease and is associated with an increased risk of fatal and nonfatal ischaemic heart disease. Few studies have examined the effect of Mg on endothelial function in healthy adults. The hypothesis is that an improvement blood vessel function measured by flow mediated dilatation after a high magnesium diet achieved using dietary supplements.

Interventions

Magnesium supplements will be used, 400 mg/day for men and 300 mg/day for women Participants will be provided with supplements by a researcher at a face to face visit to the University of South Australia Participants will be asked to take the supplements as a oral tablet each day for 7 days There is no washout period. Participants will be asked to return any unused supplements

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

BMI greater than or equal to 18 kg/m2 and less than or equal to 30 kg/m2 Systolic BP less than or equal to 140mmHg Diastolic BP less than or equal to 90mmHg Without self reported cardiovascular liver or kidney disease

Exclusion criteria

BMI <18 and >30kg/m2 Systolic BP >140mmHg Diastolic BP >90mmHg Self reported cardiovascular liver or kidney disease Taking medications that affect endothelial function e.g. sildenafil (Viagra)

Outcome results