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Treating working memory and decision-making deficits in children following traumatic brain injury.

Treating attention, speed of processing, decision-making, and working memory deficits in children following traumatic brain injury: Implementation of an attention and working memory intervention to improve adaptability and functional outcomes.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617000085370
Enrollment
31
Registered
2017-01-16
Start date
2017-04-28
Completion date
2018-09-07
Last updated
2024-06-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In children, acquired brain injury (ABI), and in particular traumatic brain injury (TBI), represents a common interruption to the course of normal development, with both international and local statistics citing an annual rate of 250–300 per 100,000 children (Kraus, 1995). Working memory refers to the capacity to temporarily store information for use in everyday activities (Alloway et al., 2006). Decision-Making is conceived as a complex interplay of high-level cold cognitive processes such as working memory, information processing, problem-solving, and hot emotional processes (Cassotti et al., 2011; Reimann and Bechara, 2010). Efficient working memory and decision-making abilities are essential as they underpin one’s performance in functional skill areas such as academic, adaptive, behavioural and social domains (Catroppa & Anderson, 2006; Ganesalingam et al, 2011; Gathercole et al., 2006; Mandalis et al, 2007; Muscara et al., 2008). Using a prospective, longitudinal design, adaptive abilities, behaviour, educational progress and everyday memory skills were investigated acutely post-injury and again at 12 and 30 months post-injury. Results suggested a strong association between injury severity and outcomes across all domains.With regard to social outcomes following childhood brain injury, deficits have been reported in many areas of social functioning and communication style, often resulting in low self-esteem, isolation, high rates of psychiatric disorder, criminal behaviour, and unemployment, and therefore poor integration into society (Anderson et al., 2009) The overall aim of the proposed study is to enhance working memory and decision-making abilities and therefore potentially strengthen academic, social, behavioural and improving quality of life for children and adolescents post traumatic brain injury (TBI). To achieve this aim, the objectives of the proposed study are: (i) To evaluate the effectiveness of Cogmed using a randomized controlled trial (RCT) to investigate improvements in working memory and decision-making, in children post-TBI, compared to children in an active control group. (ii) To determine whether these improvements in working memory and decision-making generalise into other areas of function and so also improve academic,social, behavioural, and quality of life outcomes. It is hypothesized that (i) Compared to children in the active control group, those children receiving Cogmed will display better working memory and decision-making skills immediately post-intervention and at 6 months post-intervention. (ii) Improvements in working memory and decision-making will result in improvements in functional areas such as academic, social, behavioural and quality of life outcomes.

Interventions

Cogmed (RM version) is an adaptive working memory training program designed for children aged 7-15 years.The program involves 25 sessions carried out over approximately 5 weeks. Each session runs for 40- 50 minutes and comprises 8 different games. For the first five days, children train on the same games. On day 6 and every 5th day after this a new game is introduced, replacing one of the existing games. The treatment group will be administered Cogmed (RM version). - During the initial program

Cogmed (RM version) is an adaptive working memory training program designed for children aged 7-15 years.The program involves 25 sessions carried out over approximately 5 weeks. Each session runs for 40- 50 minutes and comprises 8 different games. For the first five days, children train on the same games. On day 6 and every 5th day after this a new game is introduced, replacing one of the existing games. The treatment group will be administered Cogmed (RM version). - During the initial program appointment the coach provide an information statement to set up the program on the participants' home computer or ipad. At this meeting they will also assign each participant a unique ID number corresponding to the intervention and instruct the parent how to log into the online video conference platform. - The coach will provide one weekly support every week of the training, to ensure that the training is progressing well and answer any questions from the families through any one of online video-conferencing platforms. The online video-conference would be scheduled in the initial start- up session with the families and would last for approximately 30 minutes. The coach can monitor the training and compliance by logging into a secure server. Program compliance can be assessed as the number of sessions completed by each child, and time spent per session will be recorded. - The participants' parents will be their Cogmed Aide at home. - The intervention will be delivered online. - The intervention will include 25 sessions over a period of 5 weeks (i.e. 5 sessions each week). Each session will run for 40-50 minutes. - The intervention will run in participants' home under the supervision of their parents.

Sponsors

Cathy Catroppa
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
7 Years to 15 Years
Healthy volunteers
No

Inclusion criteria

(1) attend primary and secondary school and be between the ages of 7-15 at the time of the intervention; (2) sustained an TBI where there was head trauma associated with a) altered consciousness, as defined by Glasgow Coma Score and/or post traumatic amnesia, or b) intra-cranial abnormalities on brain scan, and, (3) injury from acute stage onwards;and, (4) evidence of reduced working memory or executive dysfunction at screening (1 SD below the mean) (5) IQ>70

Exclusion criteria

(1) non-fluency in English; (2) IQ below 70 at screening (3) other previously documented neurological or learning difficulties diagnosis; (4) severe sensory or physical impairment that affects their capacity to attend mainstream school and complete the training program: and, (5) families and/or primary caregivers who are unable to support/assist their child through to the completion of the intervention program. This will be determined through discussions with primary caregivers/parents during the recruitment phase.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 23, 2026