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The effects of leg resistance training with blood-flow restriction on unrestricted exercising arms: A validation study

The effects of leg resistance training with blood-flow restriction on the muscle size of an unrestricted exercising arm compared with an inactive arm or both an active and inactive arm with traditional resistance leg exercise in healthy males aged 18-25 years.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617000058370
Enrollment
24
Registered
2017-01-11
Start date
2015-03-01
Completion date
2016-05-01
Last updated
2017-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study comprises part of a PhD project. It aims to investigate whether light-load blood-flow restriction training in the legs can improve the muscle size of an active arm. This will be compared with the non-active arm of these participants that perform blood-flow restriction in the legs as well as either arm of participants who performed traditional light-load strength training. The purpose is to investigate whether muscle size adaptations are transferable between limbs. This will be investigated in a seven week strength training study in participants that perform either blood-flow restriction or traditional strength training in the legs.

Interventions

The intervention is a seven-week training program where participants train at the lab three days per week (twenty sessions; 45 minute duration each). Exercises performed are three sets of bicep curls (50% 1 RM) performed by the dominant arm followed by four sets of bilateral knee flexion and leg extension exercises (30% 1 RM). The leg exercises are performed with pressurised cuffs applied to the most proximal portion of the upper legs to restrict blood-flow to the working muscles. These cuffs ar

The intervention is a seven-week training program where participants train at the lab three days per week (twenty sessions; 45 minute duration each). Exercises performed are three sets of bicep curls (50% 1 RM) performed by the dominant arm followed by four sets of bilateral knee flexion and leg extension exercises (30% 1 RM). The leg exercises are performed with pressurised cuffs applied to the most proximal portion of the upper legs to restrict blood-flow to the working muscles. These cuffs are inflated to a pressure equal to 60% of the pressure required to completely occlude blood-flow through the legs. Participants are supervised/monitored throughout all training sessions by an exercise physiologist to ensure safety and adherence to the protocol. Attendance is registered for all training sessions.

Sponsors

Stuart Warmington
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
Male
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

Young healthy males (18-25 years)

Exclusion criteria

Those unable to satisfy the vigorous exercise requirements of the Adult Pre-exercise Screening System tool. People that have performed regular resistance training in the last six months People with diagnosed cardiovascular disease, uncontrolled hypertension, high resting blood pressure or heart rate. People who cannot easily comfortably perform the exercise due to musculoskeletal injuries. People in existing dependent or unequal relationships with project staff.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026