None listed
Conditions
Brief summary
The study aims to determine which bacteria, fungi, and viruses normally exist in the health sinus and chronic rhinosinusitis. Persons with healthy sinuses will be invited to participate in the study (Group 1) as well as individuals with chronic rhinosinusitis (group 2). A number of swabs will be taken from the sinuses of participants as well as a biopsy of the anterior aspect of the middle turbinate for sinus patients and analysed by laboratory techniques (microbiology and immunology).
Interventions
A total of eight swabs will be taken from each participant with chronic rhino sinusitis (CRS) at only one time point. Specifically, two swabs will be taken from each participant at each of the following locations: the vestibule, the nasopharynx, the nasal cavity and the throat. A biopsy of the middle aspect of the anterior turbinate at only one time point will also be taken from those CRS patients that are undergoing endoscopic sinus surgery. and then the resultant swabs and biopsy tissue will b
A total of eight swabs will be taken from each participant with chronic rhino sinusitis (CRS) at only one time point. Specifically, two swabs will be taken from each participant at each of the following locations: the vestibule, the nasopharynx, the nasal cavity and the throat. A biopsy of the middle aspect of the anterior turbinate at only one time point will also be taken from those CRS patients that are undergoing endoscopic sinus surgery. and then the resultant swabs and biopsy tissue will be analysed using both microbiology and genetic techniques.
Sponsors
University of Queensland
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Group 1: Controls > 18 years of age Disease free sinuses as based on examination by an Ear Nose and Throat Doctor on the same day as the swabs are taken. Group 2: Cases >18 years of age The cases have had a current diagnosis of chronic rhino sinusitis by an Ear Nose and Throat (ENT) Doctor. Specifically, the same day that the samples are being taken from the participant, the participant undergoes an examination by the ENT doctor. Please note that during this examination, the ENT doctor can distinguish chronic rhino sinusitis from acute rhino sinusitis.
Exclusion criteria
< 18 years of age Group 1: Diseased sinuses Group 2: Does not have chronic sinusitis
Outcome results
None listed