None listed
Conditions
Brief summary
This study will help us answer the question: should children with chronic cough be given inhaled corticosteroids to promote faster recovery and improve ability for children to return to their normal daily routines? This study will also evaluate whether fractional exhaled nitric oxide levels can predict short term response to inhaled corticosteroids in children with chronic cough. We hypothesise that a short (two week) course of inhaled corticosteroids will reduce cough severity in children with chronic cough, and that FeNO measurements can be used to predict this response.
Interventions
Children will be randomised to receive either inhaled corticosteroids or placebo. Children allocated to the intervention group will receive 250 micrograms fluticasone propionate twice daily for two weeks, delivered via metered dose inhaler and spacer (with or without mask, depending on age and technique).
Sponsors
Prof Anne Chang
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Months to 16 Years
Healthy volunteers
No
Inclusion criteria
Children with chronic cough. Chronic cough is defined as cough duration of >=4 weeks.
Exclusion criteria
Children who have received oral or inhaled corticosteroids in the week prior to presentation. Children who are unable to tolerate inhaled corticosteroids or adequately use spacer. Children with cerebral palsy or severe neuro-developmental abnormality. Children with physician-confirmed underlying chronic respiratory illness. Children who are immunocompromised.
Outcome results
None listed