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Are the broad cognitive improvements seen with tDCS in healthy controls a result of general or specific effects?

Are the broad cognitive improvements seen with tDCS in healthy controls a result of general or specific effects?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616001647426
Enrollment
50
Registered
2016-11-29
Start date
2016-09-16
Completion date
2019-07-08
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of the research project is to investigate whether the broad improvements seen across cognitive domains following tDCS in the healthy population are a result of general effects (i.e. improving speed of information processing) or specific effects (i.e. improving working memory capacity or social decision making ability).

Interventions

This is a randomised double-blind placebo-controlled within-subjects design. Participants will receive 20 minutes of either active or sham transcranial direct current stimulation (tDCS). Each participant will attend the Monash Alfred Psychiatry Research Centre on two occasions at least 72 hours apart. Active tDCS will be delivered using electrodes placed within the Starstim system cap. The anode, or activating, electrode will be placed over F3 according to the 10-20 international system for EE

This is a randomised double-blind placebo-controlled within-subjects design. Participants will receive 20 minutes of either active or sham transcranial direct current stimulation (tDCS). Each participant will attend the Monash Alfred Psychiatry Research Centre on two occasions at least 72 hours apart. Active tDCS will be delivered using electrodes placed within the Starstim system cap. The anode, or activating, electrode will be placed over F3 according to the 10-20 international system for EEG placement, which has been determined to be an accurate estimate of the left DLPFC. The cathodal, or reference, electrode will be placed over the right supraorbital space. Stimulation will be applied at 0.028 ma/cm for 20mins. Sham tDCS is achieved by switching off stimulation after approx. 30s ; which occurs within the software of the Starstim system allowing for administrator and patient blinding.

Sponsors

A/ Prof Kate Hoy
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

Inclusion Criteria 1. Are voluntary and competent to consent, 2. Are right handed, 3. Are between the ages of 18 and 45 years, 4. Are native English speakers 5. Have no history of neurological illness, mental illness or traumatic brain injury.

Exclusion criteria

Exclusion Criteria 1. Are pregnant or lactating, 2. Currently taking any psychoactive medications, 3. Have metal anywhere in the head, except the mouth. This includes metallic objects such as screws, plates and clips from surgical procedures.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026