None listed
Conditions
Brief summary
This study aims to determine the effect of exercise training on heart function in breast cancer patients undergoing Anthracycline based chemotherapy and to evaluate the use of exercise Cardiac Magnetic Resonance, a novel imaging technique. Who is it for? You may be eligible to join this study if you are between the ages 18 and 70 years old, have been diagnosed with breast cancer and are scheduled for Anthracycline-based chemotherapy. Study details Participants can chose which group they wish to join. Participants can select the intervention group where they will follow a personalised exercise program 2 times per week for 60minutes at the Baker IDI Heart and Diabetes institute and one home based (unsupervised) session for 100min for the duration of their Anthracycline chemotherapy. Whilst participants who elect to be in the control group will not follow an exercise program but are encouraged to exercise at their discretion. All participants will undergo an echocardiogram, VO2 max test and exercise Cardiac Magnetic Resonance (CMR) at baseline and 3 weeks after the last anthracycline treatment cycle. The exercise CMR is a novel technique hypothesized to aid in earlier diagnosis of heart failure. Participants will pedal a specially adapted cycle while lying in the narrow tube of the MRI machine.
Interventions
The exercise training will be individualised for each participant based upon the cardiopulmonary exercise testing and three-repetition maximum test. Each participant will complete two supervised exercise sessions by an accredited exercise physiologist (4+ years experience sports medicine/oncology) for 60 minutes and one unsupervised home-based exercise each week for approximately 100 minutes. Participants will perform the exercise training at Baker IDI Heart and Diabetes Institute Specialist Cl
The exercise training will be individualised for each participant based upon the cardiopulmonary exercise testing and three-repetition maximum test. Each participant will complete two supervised exercise sessions by an accredited exercise physiologist (4+ years experience sports medicine/oncology) for 60 minutes and one unsupervised home-based exercise each week for approximately 100 minutes. Participants will perform the exercise training at Baker IDI Heart and Diabetes Institute Specialist Clinic gymnasium and will be instructed to perform the aerobic exercise training program (32 minutes) and the resistance training program (28 minutes). The aerobic training program consists of interval stationary cycling beginning at 70% of their peak oxygen consumption (as determined by the cardiopulmonary exercise testing) measured in workload (watts) and progressed each week for 12 weeks. The resistance training program will consist of 4-5 exercises, 3 sets of 12-15 repetitions with a 30 second recovery in between each set. The load (kilograms) and intensity will start at 60-70% of one-repetition maximum and increase by 10 percentage each week. Both programs will follow a periodisation method that accounts for chemotherapy related fatigue, sickness and illness, specifically during the week of chemotherapy administration. At home, participants will complete continuous walking at a moderate intensity (55%-70% of VO2peak) for 100 minutes. Adherence will be monitored. The accredited exercise physiologist completes clinical notes after each session (exercise training sheet, exercise diary). Each participant will complete a total of 24 sessions (supervised by an accredited exercise physiologist) and 12 unsupervised sessions)
Sponsors
Baker IDI Heart and Diabetes Research Institute
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Diagnosed with Breast Cancer Scheduled for Anthracycline-based chemotherapy. Capable of walking up two flights of stairs
Exclusion criteria
Sustained irregular heartbeat (eg atrial fibrillation). Contraindication to Cardiac MRI such as implanted metallic device (eg pacemaker).
Outcome results
None listed