None listed
Conditions
Brief summary
Genetic factors may alter the pharmacokinetic and pharmacodynamic properties of certain analgesic agents and therefore can modify individual clinical response to their administration. Although polymorphisms of enzymes responsible for the metabolism and transport of various drugs eventually affect their pharmacokinetics, other polymorphisms may also alter the pharmacodynamics of the particular drug. Patients undergoing elective thyroidectomy have different requirements in perioperative analgesia with short action opiate. In order to investigate the possible association of the response of these patients to remifentanil with the polymorphisms of SLC6A4 andABCB1 genes we will administer remifentanyl with Target Controlled Infusion technique in patients undergoing elective thyroidectomy. Preoperatively all patients will be evaluated with Hamilton anxiety scale rating test. The total remifentanyl requirements as well as the subjective postoperative pain will be associated with the polymorphisms of SLC6A4 andABCB1 genes.
Interventions
Preoperative assesment of anxiety using the Hamilton anxiety scale rating.
Administration of intravenous Remifentanil with Target- Controlled-Infusion technique (TCI) in patients undergoing elective thyroidectomy
Remifentanil will be the exclusive opioid analgesic given during the whole anesthetic and surgical procedure
Remifentanil serum target levels will range between 1-2.5 ng/ml
The approximate duration of surgery will be 60-90 minutes.
Indentification of polymorphism of genes SLC01A2 and AB
Preoperative assesment of anxiety using the Hamilton anxiety scale rating. Administration of intravenous Remifentanil with Target- Controlled-Infusion technique (TCI) in patients undergoing elective thyroidectomy Remifentanil will be the exclusive opioid analgesic given during the whole anesthetic and surgical procedure Remifentanil serum target levels will range between 1-2.5 ng/ml The approximate duration of surgery will be 60-90 minutes. Indentification of polymorphism of genes SLC01A2 and ABCB1 Correlation of gene polymorphisms with remifentanil requirements as well as its efficacy and safety
Sponsors
Aristotle University of Thessaloniki, Greece
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
Patients aged 18-79 years, Preoperative ASA 1-2, Normal levels of thyroid hormones Elective thyroidectomy operation Informed consent for enrollment given
Exclusion criteria
Patients aged <18 and> 80 years, ranking in ASA> 3, with a history of chronic pain and / or systemic use of analgesics drugs before surgery, surgical operation non elective (emergency), severe disruption of thyroid hormone levels, pregnancy, neuropsychiatric disorders.
Outcome results
None listed